L-ALANINE BENZYL ESTER

Base Information

• Chemical Name: L-ALANINE BENZYL ESTER
• CAS No.: 17831-01-5
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol file: 17831-01-5.mol

Synonyms:H-Ala-OBzl;L-ALANINE BENZYL ESTER;L-Alanine, phenylmethyl ester;

Chemical Property of L-ALANINE BENZYL ESTER

Chemical Property:

• PSA: 52.32000
• LogP: 1.77730

Purity/Quality:

98%Min ^*data from raw suppliers

L-ALANINE BENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-ALANINE BENZYL ESTER

There total 24 articles about L-ALANINE BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

L-alanine benzyl ester p-toluenesulfonate (42854-62-6) → H-Ala-OBzl (17831-01-5)

Guidance literature:

With triethylamine; In water; toluene; at 5 ℃; for 2.5h;

Reference yield: 89.0%

L-alanine benzyl ester trifluoroacetate salt → H-Ala-OBzl (17831-01-5)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 20 ℃;

DOI:10.1002/chem.202005351

Reference yield: 76.5%

benzyl chloride (100-44-7) + rac-Ala-OH (302-72-7,25191-17-7,18875-37-1) → DL-alanine benzyl ester (17831-01-5,17831-02-6,46229-47-4)

Guidance literature:

rac-Ala-OH; With potassium carbonate; In acetone; at 35 ℃; for 0.5h;

benzyl chloride; With tetrabutylammomium bromide; In acetone; for 12h; Inert atmosphere;

upstream raw materials:

N-Cbz-Ala

L-alanin

p-toluenesulfonic acid monohydrate

benzyl alcohol

Downstream raw materials:

N-(N^α,N^δ,N^ω-tris-benzyloxycarbonyl-L-arginyl)-L-alanine benzyl ester

N-(bis-benzyloxy-phosphoryl)-alanine benzyl ester

Z-Gly-Ala-OBzl

Boc-Asp(OBzl)-Ala-OBzl

Refernces

• 1、 -. "MACROCYCLIZATION OF PEPTIDOMIMETICS". Page/Page column 36; 41-42. . Retrieved 2019/10/19.
• 2、 -. "A synthetic amino acid N-methylation method and its product and application (by machine translation)". Paragraph 0053; 0054; 0055. . Retrieved 2016/11/09.