5-bromo-2-chlorobenzene-1-sulfonyl chloride

Base Information

• Chemical Name: 5-bromo-2-chlorobenzene-1-sulfonyl chloride
• CAS No.: 81226-68-8
• Molecular Formula: C6H3BrCl2O2S
• Molecular Weight: 289.965
• Hs Code.: 2904909090
• Mol file: 81226-68-8.mol

Synonyms:5-Bromo-2-chlorobenzenesulfonyl chloride;

Chemical Property of 5-bromo-2-chlorobenzene-1-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 343.367oC at 760 mmHg
• Flash Point: 161.463oC
• PSA: 42.52000
• Density: 1.88g/cm3
• LogP: 4.11080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-2-chlorobenzene-1-sulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-chlorobenzene-1-sulfonyl chloride

There total 2 articles about 5-bromo-2-chlorobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-bromo-2-chloroaniline (60811-17-8) → 5-bromo-2-chlorobenzene-1-sulfonyl chloride (81226-68-8)

Guidance literature:

5-bromo-2-chloroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With sulfur dioxide; acetic acid; copper(l) chloride; In water; at 0 - 20 ℃; for 2.25h;

DOI:10.1021/jm300403a

Reference yield:

5-bromo-2-chloroaniline hydrochloride (15327-48-7) → 5-bromo-2-chlorobenzene-1-sulfonyl chloride (81226-68-8)

Guidance literature:

5-bromo-2-chloroaniline hydrochloride; With hydrogenchloride; In water; acetonitrile; at 5 ℃; for 0.166667h;

With sodium nitrite; In water; acetonitrile; at -5 ℃; for 0.25 - 0.333333h;

With sulfur dioxide; copper dichloride; In water; acetic acid; acetonitrile; at 0 - 20 ℃; for 1.5h;

Reference yield: 99.0%

5-bromo-2-chlorobenzene-1-sulfonyl chloride (81226-68-8) + cyclohexylamine (108-91-8,157973-60-9) → 5-bromo-2-chloro-N-cyclohexyl-benzenesulfonamide (903595-97-1)

Guidance literature:

5-bromo-2-chlorobenzene-1-sulfonyl chloride; cyclohexylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -5 - 20 ℃; for 20.75h;

With hydrogenchloride; In dichloromethane; water; at -10 ℃;

upstream raw materials:

5-bromo-2-chloroaniline hydrochloride

5-bromo-2-chloroaniline

Downstream raw materials:

5-bromo-2-chloro-N-(2-(2-methoxy-phenyl)-ethyl)-benzenesulfonamide

5-bromo-2-chloro-N-cyclohexyl-benzenesulfonamide

5-bromo-2-chloro-benzenesulfonic acid anilide

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