3-(Bromomethyl)-4-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole

Base Information

Chemical Name:3-(Bromomethyl)-4-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole
CAS No.:81321-66-6
Molecular Formula:C16H11BrClFN2
Molecular Weight:365.632
Hs Code.:
DSSTox Substance ID:DTXSID30512343
Wikidata:Q82371538

Synonyms:81321-66-6;3-(Bromomethyl)-4-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole;SCHEMBL10882067;DTXSID30512343

Suppliers and Price of 3-(Bromomethyl)-4-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-(Bromomethyl)-4-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:363.97782
Heavy Atom Count:21
Complexity:330

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CN(N=C2CBr)C3=CC=C(C=C3)F)Cl

Technology Process of 3-(Bromomethyl)-4-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole

There total 5 articles about 3-(Bromomethyl)-4-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 81321-57-5
<4-(4-Chlorphenyl)-1-(4-fluorphenyl)-3-pyrazolyl>-methanol

: 81321-66-6
3-Brommethyl-4-(4-chlorphenyl)-1-(4-fluorphenyl)-pyrazol

Guidance literature:: With hydrogen bromide; In water; at 80 - 90 ℃; for 8h;

Reference yield:

: 81321-45-1
4-(4-Chlorphenyl)-1-(4-fluorphenyl)-pyrazol-3-carbonsaeure-ethylester

: 81321-66-6
3-Brommethyl-4-(4-chlorphenyl)-1-(4-fluorphenyl)-pyrazol

Guidance literature:: Multi-step reaction with 2 steps

1: 98.5 percent / diisobutylaluminum hydride / toluene / 1.) 15 min. -10 deg C_. 2.) 2 h, room temp.

2: 89 percent / 63percent HBr / H₂O / 8 h / 80 - 90 °C

With hydrogen bromide; diisobutylaluminium hydride; In water; toluene;

Reference yield:

: 81321-40-6
4-(4-Chlorphenyl)-1-(4-fluorphenyl)-5-morpholino-4,5-dihydro-pyrazol-3-carbonsaeure-ethylester

: 81321-66-6
3-Brommethyl-4-(4-chlorphenyl)-1-(4-fluorphenyl)-pyrazol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / HCl / dioxane; H₂O / 1 h / 100 °C

2: 98.5 percent / diisobutylaluminum hydride / toluene / 1.) 15 min. -10 deg C_. 2.) 2 h, room temp.

3: 89 percent / 63percent HBr / H₂O / 8 h / 80 - 90 °C

With hydrogenchloride; hydrogen bromide; diisobutylaluminium hydride; In 1,4-dioxane; water; toluene;