N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide
CAS No.:81654-49-1
Molecular Formula:C11H13F3N2O2
Molecular Weight:262.232
Hs Code.:
DSSTox Substance ID:DTXSID10510347
Wikidata:Q82368577

Synonyms:N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide;N-[2-(3-amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoro acetamide;N-[2-(3-Amino-4-methoxyphenyl]ethyl]-2,2,2-trifluoro acetamide;N-[2-[3-Amino-4-methoxyphenyl]ethyl]-2,2,2-trifluoro acetamide;81654-49-1;SCHEMBL5913864;DTXSID10510347;N-[2-(3amino-4-methoxyphenyl]ethyl]-2,2,2-trifluoro acetamide

Suppliers and Price of N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:262.09291215
Heavy Atom Count:18
Complexity:284

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCNC(=O)C(F)(F)F)N

Technology Process of N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

There total 4 articles about N-[2-(3-Amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 81654-48-0
N-<2-(4-methoxy-3-nitrophenyl)ethyl>-2,2,2-trifluoroacetamide

: 81654-49-1
N-[2-(3-amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoro acetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 4h;

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 81654-49-1
N-[2-(3-amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoro acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 88.4 percent / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 84.5 percent / HNO₃, TFA / 2 h / Ambient temperature

3: 76.3 percent / hydrazine hydrate / Raney nickel / ethanol / 2 h / 15 °C

With nitric acid; hydrazine hydrate; trifluoroacetic acid; nickel; In ethanol; dichloromethane;
DOI:10.1021/jm00156a010

Reference yield:

: 81654-47-9
2,2,2-Trifluoro-N-[2-(4-methoxyphenyl)ethyl]acetamide

: 81654-49-1
N-[2-(3-amino-4-methoxyphenyl)ethyl]-2,2,2-trifluoro acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84.5 percent / HNO₃, TFA / 2 h / Ambient temperature

2: 76.3 percent / hydrazine hydrate / Raney nickel / ethanol / 2 h / 15 °C

With nitric acid; hydrazine hydrate; trifluoroacetic acid; nickel; In ethanol;
DOI:10.1021/jm00156a010