1-(2-Fluoro-4-trifluoroMethyl-phenyl)-piperazine

Base Information

• Chemical Name: 1-(2-Fluoro-4-trifluoroMethyl-phenyl)-piperazine
• CAS No.: 817170-70-0
• Molecular Formula: C₁₁H₁₂F₄N₂
• Molecular Weight: 248.223
• Mol file: 817170-70-0.mol

Synonyms:1-(2-Fluoro-4-trifluoromethylphenyl)piperazine;1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine;

Chemical Property of 1-(2-Fluoro-4-trifluoroMethyl-phenyl)-piperazine

Chemical Property:

• PSA: 15.27000
• LogP: 2.64790
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-[2-Fluoro-4-(trifluoromethyl)phenyl]piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Fluoro-4-trifluoroMethyl-phenyl)-piperazine

There total 4 articles about 1-(2-Fluoro-4-trifluoroMethyl-phenyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (847547-01-7) → 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine (817170-70-0)

Guidance literature:

4-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 80 ℃; for 2h;

With sodium carbonate; In water;

Reference yield: 55.5%

piperazine (110-85-0) + 1-chloro-2-fluoro-4-(trifluoromethyl)benzene (32137-20-5) → 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine (817170-70-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; ruphos; In 1,4-dioxane; at 100 ℃; for 1h;

DOI:10.3390/molecules26113182

Reference yield:

piperazine (110-85-0) + 1-bromo-2-fluoro-4-(trifluoromethyl)benzene (40161-54-4) → 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine (817170-70-0)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In toluene; at 130 ℃; for 3h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

4-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

piperazine

1-bromo-2-fluoro-4-(trifluoromethyl)benzene

1-chloro-2-fluoro-4-(trifluoromethyl)benzene

Refernces

• 1、 -. "2-Substituted-oxy-5-methylsulfonyl pyridine piperazine acidamide analogue and preparation method and application thereof". Paragraph 0097; 0098; 0099; 0100. . Retrieved 2016/10/08.
• 2、 -. "CETP INHIBITORS". Page/Page column 156. . Retrieved 2008/06/13.