32137-20-5

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-3-FLUOROBENZOTRIFLUORIDE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-3-FLUOROBENZOTRIFLUORIDE is utilized as an intermediate in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Fine Chemicals Production:
4-CHLORO-3-FLUOROBENZOTRIFLUORIDE is also employed as an intermediate in the manufacture of fine chemicals, where its unique properties allow for the creation of specialized chemical products used in various applications.
Used as a Synthesis Reagent:
4-CHLORO-3-FLUOROBENZOTRIFLUORIDE is used as a reagent in the synthesis of a variety of organic compounds, facilitating chemical reactions that lead to the formation of desired products in research and industrial settings.
Safety Considerations:
It is important to handle 4-CHLORO-3-FLUOROBENZOTRIFLUORIDE with care due to its potential harmful effects if ingested, inhaled, or absorbed through the skin. Additionally, it can cause irritation to the eyes and skin, necessitating proper safety measures during its use in laboratories and industrial processes.

Upstream product

• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 
• 535-52-4 2-fluoro-5-(trifluoromethyl)aniline 
• 32137-19-2 1,2-difluoro-4-(trifluoromethyl)benzene 
• 454-78-4 3-bromo-4-chlorobenzotrifluoride 

Downstream Products

• 186517-41-9 3-chloro-2-fluoro-6-(trifluoromethyl)benzoic acid 
• 817170-70-0 1-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine 

Relevant academic research and scientific papers

Large-scale preparation of aromatic fluorides via electrophilic fluorination with functionalized aryl- or heteroarylmagnesium reagents

Functionalized aryl- or heteroarylmagnesium reagents, prepared from the corresponding bromides or iodides using halogen-magnesium exchange or direct magnesium insertion in the presence of lithium chloride, reacted smoothly with N-fluorobenzenesulfonimide, (PhSO2)2NF, in the mixed solvent (4:1 CH2Cl2-perfluorodecalin) to give the corresponding aromatic fluorides in moderate to good yields. Georg Thieme Verlag Stuttgart · New York.

Convenient electrophilic fluorination of functionalized aryl and heteroaryl magnesium reagents

"Chemical Equation Presented" Cive me an "F": Electrophilic fluorination of various aromatic and heteroaromatic Grignard reagents is smoothly performed with (PhSO2)2NF as fluorinating agent in a 4:1 mixture of CH2Cl2/ perfluorodecalin (see scheme). This solvent system allows minimization of most side reactions.

AROMATIC FLUORINE CHEMISTRY. PART 1. 3,4-DIFLUOROBENZOIC ACID AND DERIVATIVES VIA 3,4-DIFLUOROBENZOTRIFLUORIDE

The preparation of 3,4-difluorobenzotrifluoride from 3,4-dichlorobenzotrifluoride by a KF exchange reaction is described.The conversion of 3,4-difluorobenzotrifluoride to 3,4-difluorobenzoic acid and derivatives is also reported.

Preparation of 3,4-difluorobenzotrifluoride

3,4-Difluorobenzotrifluoride is prepared by contacting a 3,4-dihalobenzotrifluoride with an effective amount of KF or CsF in a polar aprotic solvent at an elevated temperature under substantially anhydrous conditions. The product can be removed as it is formed or the reaction may be run at the autogenous pressures generated by the reaction mixture in a sealed reactor.

THE FLUORINATION OF ORGANIC SUBSTRATES WITH TETRAPHENYLPHOSPHONIUM HYDROGENDIFLUORIDE

Tetraphenylphosphonium hydrogendifluoride acts as a powerful source of F- in various reactions with organic substrates to give fluorine containing products.