Z-GLN-GLY-OH

Base Information

• Chemical Name: Z-GLN-GLY-OH
• CAS No.: 6610-42-0
• Molecular Formula: C15H19N3O6
• Molecular Weight: 337.332
• Hs Code.: 2924299090
• Nikkaji Number: J1.502.793B
• Mol file: 6610-42-0.mol

Synonyms:Z-Gln-Gly;N-carbobenzyloxy glutaminyl glycine;benzyloxycarbonyl-Gln-Gly;Cbz-L-Gln-Gly;

Chemical Property of Z-GLN-GLY-OH

Chemical Property:

• Vapor Pressure: 1.67E-23mmHg at 25°C
• Melting Point: 131 - 132°C
• Boiling Point: 748°Cat760mmHg
• PKA: 3.38±0.10(Predicted)
• Flash Point: 406.2°C
• PSA: 147.82000
• Density: 1.339g/cm³
• LogP: 1.22980
• Storage Temp.: −20°C
• Solubility.: Chloroform (Slightly, Sonicated) Methanol (Slightly), Water (Slightly, Sonicated
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 337.12738533
• Heavy Atom Count: 24
• Complexity: 462

Purity/Quality:

98%,99%, ^*data from raw suppliers

Z-Gln-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC(CCC(=O)N)C(=O)NCC(=O)O
• Isomeric SMILES: C1=CC=C(C=C1)COC(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)O
• Uses: γ-Glutamyl donor substrate used in spectrophotometric determination of transglutaminase (TGase) activity. Z-Gln-Gly was used to enzymatically synthesize N-linked neoglycoproteins.

Technology Process of Z-GLN-GLY-OH

There total 8 articles about Z-GLN-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-L-Gln (2650-64-8) → α-N-carbobenzyloxy-L-glutamine-glycine (6610-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N; DMAP / acetonitrile / 0.75 h / 20 °C

2: Et₃N / acetonitrile; H₂O / 1.67 h / 20 °C

With dmap; triethylamine; In water; acetonitrile;

DOI:10.1016/S0040-4039(02)01840-3

Reference yield:

Z-Gln-Gly-OEt (2731-88-6) → α-N-carbobenzyloxy-L-glutamine-glycine (6610-42-0)

Guidance literature:

With sodium hydroxide; acetone;

DOI:10.1557/JMR.2002.0388

Reference yield:

N2-benzyloxycarbonyl-L-glutamine-(4-nitro-phenyl ester) (7763-16-8) + glycine (56-40-6,18875-39-3,25718-94-9) → α-N-carbobenzyloxy-L-glutamine-glycine (6610-42-0)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 1.66667h;

DOI:10.1016/S0040-4039(02)01840-3

upstream raw materials:

Z-Gln-Gly-OEt

N-(O-ethyl-N-benzyloxycarbonyl-L-α-glutamyl)-glycine

N²-benzyloxycarbonyl-L-glutamine-(4-nitro-phenyl ester)

glycine

Downstream raw materials:

Cbz-L-Gln-Gly-Gly

[4-(3-amino-2-hydroxy-propylcarbamoyl)-2-benzyloxycarbonylamino-butyrylamino]-acetic acid

Z-α-L-Glutamyl-(γ-hydrazid)-glycin

Refernces