2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-1-methyl-2-[7 -[(methylsulfonyl)oxy]-1H-indol-3-yl]ethyl]amino]ethyl]phenyl]-

Base Information

Chemical Name:2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-1-methyl-2-[7 -[(methylsulfonyl)oxy]-1H-indol-3-yl]ethyl]amino]ethyl]phenyl]-
CAS No.:820216-52-2
Molecular Formula:C₃₀H₄₁N₃O₆S₃Si
Molecular Weight:663.956
Hs Code.:

2-Thiophenesulfonamide,
N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-1-methyl-2-[7
-[(methylsulfonyl)oxy]-1H-indol-3-yl]ethyl]amino]ethyl]phenyl]-

Synonyms:

Suppliers and Price of 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-1-methyl-2-[7 -[(methylsulfonyl)oxy]-1H-indol-3-yl]ethyl]amino]ethyl]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-1-methyl-2-[7 -[(methylsulfonyl)oxy]-1H-indol-3-yl]ethyl]amino]ethyl]phenyl]-

Chemical Property:

PSA：171.59000
LogP:9.27780

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-1-methyl-2-[7 -[(methylsulfonyl)oxy]-1H-indol-3-yl]ethyl]amino]ethyl]phenyl]-

There total 8 articles about 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-1-methyl-2-[7 -[(methylsulfonyl)oxy]-1H-indol-3-yl]ethyl]amino]ethyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 244081-38-7
(2R)-7-benzyloxy-3-[2-(tert-butoxycarbonylamino)propyl]-1H-indole

: 820216-52-2
methanesulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / HCO₂NH₄ / Pd/C / methanol

2: TEA / CH₂Cl₂

3: HCl / ethyl acetate

4: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 820216-52-2
methanesulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide

2: aq. NH₄Cl; Fe / ethanol

3: pyridine / CH₂Cl₂

4: i-PrNEt₂; KI / acetonitrile

With pyridine; 1H-imidazole; N,N-diethyl-N-isopropylamine; iron; ammonium chloride; potassium iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 820216-52-2
methanesulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: BH₃; (R)-2-methyl-CBS-oxazaborolidine / tetrahydrofuran

2: imidazole / dimethylformamide

3: aq. NH₄Cl; Fe / ethanol

4: pyridine / CH₂Cl₂

5: i-PrNEt₂; KI / acetonitrile

With pyridine; 1H-imidazole; N,N-diethyl-N-isopropylamine; borane; iron; ammonium chloride; potassium iodide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035