Methyl 4-(4-(pyridin-4-YL)phenyl)thiophene-2-carboxylate

Base Information

Chemical Name:Methyl 4-(4-(pyridin-4-YL)phenyl)thiophene-2-carboxylate
CAS No.:820224-07-5
Molecular Formula:C17H13NO2S
Molecular Weight:295.362
Hs Code.:
DSSTox Substance ID:DTXSID40696986

Synonyms:820224-07-5;METHYL 4-(4-(PYRIDIN-4-YL)PHENYL)THIOPHENE-2-CARBOXYLATE;Methyl 4-[4-(pyridin-4-yl)phenyl]thiophene-2-carboxylate;SCHEMBL6664021;DTXSID40696986;A840235

Suppliers and Price of Methyl 4-(4-(pyridin-4-YL)phenyl)thiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methyl 4-(4-(pyridin-4-YL)phenyl)thiophene-2-carboxylate

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:295.06669983
Heavy Atom Count:21
Complexity:349

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC(=CS1)C2=CC=C(C=C2)C3=CC=NC=C3

Technology Process of Methyl 4-(4-(pyridin-4-YL)phenyl)thiophene-2-carboxylate

There total 1 articles about Methyl 4-(4-(pyridin-4-YL)phenyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26137-07-5
4-(4-bromo-phenyl)-thiophene-2-carboxylic acid methyl ester

: 1692-15-5
4-pyridylboronic acid

: 820224-07-5
methyl 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 80 ℃;
DOI:10.1016/j.bmcl.2005.05.079

Reference yield: 44.5%

: 820224-07-5
methyl 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylate

: 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 50 ℃;

Reference yield:

: 820224-07-5
methyl 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylate

: 766536-21-4
(S)-3-Phenyl-3-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. LiOH / ethanol

2.1: HATU; DIEA / dimethylformamide / 20 °C

2.2: aq. LiOH / ethanol

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.079