(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID

Base Information

Chemical Name:(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID
CAS No.:766536-21-4
Molecular Formula:C₂₅H₂₀N₂O₃S
Molecular Weight:428.511
Hs Code.:
Mol file:766536-21-4.mol

Synonyms:

Suppliers and Price of (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Axon Medchem
PF00356231 98%
5 mg
$ 148.50

American Custom Chemicals Corporation
(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)THIOPHENE-2-CARBONYL]AMINO)PROPIONIC ACID 95.00%
25MG
$ 1232.62

American Custom Chemicals Corporation
(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)THIOPHENE-2-CARBONYL]AMINO)PROPIONIC ACID 95.00%
5MG
$ 320.10

Total 16 raw suppliers

Chemical Property of (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

PF00356231 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID

There total 4 articles about (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylic acid

: 766536-21-4
(S)-3-Phenyl-3-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2-carbonyl]-amino}-propionic acid

Guidance literature:: 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylic acid; (2R)-amino(phenyl)propanoate; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

With lithium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2005.05.079

Reference yield:

: 820224-07-5
methyl 4-[4-(pyridin-4-yl)phenyl]thiophen-2-carboxylate

: 766536-21-4
(S)-3-Phenyl-3-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. LiOH / ethanol

2.1: HATU; DIEA / dimethylformamide / 20 °C

2.2: aq. LiOH / ethanol

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.079

Reference yield:

: 26137-07-5
4-(4-bromo-phenyl)-thiophene-2-carboxylic acid methyl ester

: 766536-21-4
(S)-3-Phenyl-3-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Pd(PPh₃)4; aq. K₃PO₄ / 1,2-dimethoxy-ethane / 80 °C

2.1: aq. LiOH / ethanol

3.1: HATU; DIEA / dimethylformamide / 20 °C

3.2: aq. LiOH / ethanol

With lithium hydroxide; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.05.079