Morpholine, 4-(3-bromo-4-hydroxybenzoyl)-

Base Information

• Chemical Name: Morpholine, 4-(3-bromo-4-hydroxybenzoyl)-
• CAS No.: 820232-27-7
• Molecular Formula: C11H12BrNO3
• Molecular Weight: 286.125
• DSSTox Substance ID: DTXSID70467368
• Nikkaji Number: J2.144.390E
• Wikidata: Q82294302
• Mol file: 820232-27-7.mol

Synonyms:Morpholine, 4-(3-bromo-4-hydroxybenzoyl)-;820232-27-7;DTXSID70467368

Chemical Property of Morpholine, 4-(3-bromo-4-hydroxybenzoyl)-

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 285.00006
• Heavy Atom Count: 16
• Complexity: 256

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)C2=CC(=C(C=C2)O)Br

Technology Process of Morpholine, 4-(3-bromo-4-hydroxybenzoyl)-

There total 1 articles about Morpholine, 4-(3-bromo-4-hydroxybenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 3-bromo-4-hydroxybenzoyl chloride (888731-49-5) → 3-bromo-4-hydroxymorpholinobenzamide (820232-27-7)

Guidance literature:

morpholine; 3-bromo-4-hydroxybenzoyl chloride; In dichloromethane; at 0 - 15 ℃; for 2h;

With hydrogenchloride; In dichloromethane; water; at 0 ℃; for 1h; pH=1 - 2; Product distribution / selectivity;

Reference yield: 97.6%

dicyanozinc (557-21-1) + 3-bromo-4-hydroxymorpholinobenzamide (820232-27-7) → 5-morpholinocarbonyl-2-hydroxybenzonitrile (820232-28-8)

Guidance literature:

With bromine; triphenylphosphine; zinc; 5%-palladium/activated carbon; In ISOPROPYLAMIDE; at 20 - 120 ℃; for 1h; Product distribution / selectivity;

Reference yield:

dicyanozinc (557-21-1) + 3-bromo-4-hydroxymorpholinobenzamide (820232-27-7) → (4-hydroxyphenyl)(morpholino)methanone (18137-25-2) + 5-morpholinocarbonyl-2-hydroxybenzonitrile (820232-28-8)

Guidance literature:

With bromine; triphenylphosphine; zinc; palladium on activated charcoal; In dimethyl amine; at 115 ℃; for 4h;

DOI:10.1016/j.tetlet.2005.01.098

upstream raw materials:

morpholine

3-bromo-4-hydroxybenzoyl chloride

Downstream raw materials:

(4-hydroxyphenyl)(morpholino)methanone

5-morpholinocarbonyl-2-hydroxybenzonitrile