18137-25-2

Basic information

• Product Name: CHEMBRDG-BB 5581642
• Synonyms: OTAVA-BB BB0117380081;CHEMBRDG-BB 5581642;4-(4-MORPHOLINYLCARBONYL)PHENOL;AKOS BBS-00008688;OTAVA-BB 0117380081;UKRORGSYN-BB BBV-102612;4-(4-morpholinylcarbonyl)phenol(SALTDATA: FREE);(4-HYDROXYPHENYL)(MORPHOLINO)METHANONE
• CAS NO: 18137-25-2
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Mol File: 18137-25-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 422.6 °C at 760 mmHg
• Flash Point: 209.4 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 9.71E-08mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CHEMBRDG-BB 5581642(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5581642(18137-25-2)
• EPA Substance Registry System: CHEMBRDG-BB 5581642(18137-25-2)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 18137-25-2(Hazardous Substances Data)

Usage

Uses

(4-Hydroxyphenyl)(morpholino)methanone is used in preparation of morpholine benzamides as drugs for treatment of neuropsychiatric disorders.

InChI:InChI=1/C11H13NO3/c13-10-3-1-9(2-4-10)11(14)12-5-7-15-8-6-12/h1-4,13H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 201230-82-2 carbon monoxide 
• 540-38-5 p-Iodophenol 
• 106-41-2 4-bromo-phenol 
• 160816-43-3 4-(4-morpholinylcarbonyl)-benzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 99-96-7 4-hydroxy-benzoic acid 
• 100743-91-7 4-(4-acetoxy-benzoyloxy)-benzoic acid ethyl ester 
• 27914-73-4 4-acetoxybenzoyl chloride 
• 110007-32-4 4-ethoxycarbonylphenyl 4-hydroxybenzoate 
• 402-45-9 4-hydroxybenzotrifluoride 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 557-21-1 dicyanozinc 
• 820232-27-7 3-bromo-4-hydroxymorpholinobenzamide 

Downstream Products

• 634903-80-3 N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[4-(4-morpholinylcarbonyl)phenyl]-1-benzothiophene-2-carboxamide hydrochloride 
• 634904-42-0 N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-7-[4-(4-morpholinylcarbonyl)phenyl]-1-benzothiophene-2-carboxamide hydrochloride 
• 634904-13-5 N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[4-(morpholinylcarbonyl)phenyl]-1-benzofuran-2-carboxamide hydrochloride 
• 634905-13-8 4-(morpholine-4-carbonyl)phenyl trifluoromethanesulfonate 
• 1160829-27-5 C₂₄H₃₀BNO₅ 

Relevant articles and documents

Decarboxylative Hydroxylation of Benzoic Acids

Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.

Morpholine benzamide compound and application thereof

The invention belongs to the field of medical treatment, and particularly relates to a morpholine benzamide compound and application thereof, the morpholine benzamide compound has a compound structureshown as a formula (A), and the compound can be applied

An efficient procedure for chemoselective amidation from carboxylic acid and amine (ammonium salt) under mild conditions

Presented here is an efficient one-pot and catalyst-free procedure for the synthesis of amides starting from carboxylic acids and amine/ammonium salts using 2,2-dichloro-1,3-diisopropylimidazolidine-4,5-dione as the coupling agent. Reactions can proceed smoothly even with those bearing thermosensitive group(s) at ambient temperature, and the corresponding products of primary, secondary and tertiary amides can be afforded in moderate to excellent yields of up to 96%.