Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-

Base Information

Chemical Name:Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-
CAS No.:85732-25-8
Molecular Formula:C22H26N2O5
Molecular Weight:398.4522
Hs Code.:
DSSTox Substance ID:DTXSID601006346

Synonyms:85732-25-8;Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-;SCHEMBL10916899;DTXSID601006346;LS-145944;1'-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]spiro[3,1-benzoxazine-4,4'-piperidin]-2-ol

Suppliers and Price of Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-

Chemical Property:

Boiling Point:543.3°Cat760mmHg
Flash Point:282.4°C
Density:1.31g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:398.18417193
Heavy Atom Count:29
Complexity:565

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C(CN2CCC3(CC2)C4=CC=CC=C4NC(=O)O3)O)OC

Technology Process of Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)-

There total 6 articles about Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-(3,4-dimethoxyphenyl)-2-hydroxyethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

: 85732-24-7
1'-(3,4-dimethoxybenzoylmethyl)spiro<4H-3,1-benzoxazine-4,4'-piperidin>-2(1H)-one

: 85732-25-8
1'-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>spiro<4H-3,1-benzoxazine-4,4'-piperidin>-2(1H)-one

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 72h; Ambient temperature;
DOI:10.1248/cpb.33.1129

Reference yield:

: 65854-91-3
N-(4-chlorophenyl)-2,2-dimethylpropionamide

: 85732-25-8
1'-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>spiro<4H-3,1-benzoxazine-4,4'-piperidin>-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 45.4 percent / n-butyllithium / hexane; tetrahydrofuran / -5 °C

2: 62.4 percent / 3 N H₂SO₄ / H₂O / 16 h / Heating

3: pyridine / 0 °C

4: aq. NaOH / methanol

5: 85.5 percent / hydrogen, 1N HCl / 10percent Pd-C / H₂O; methanol / 20 h / 40 °C

6: 93.2 percent / TEA / ethanol / Ambient temperature

7: 91.9 percent / NaBH₄ / ethanol / 72 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; TEA; sulfuric acid; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; water;
DOI:10.1248/cpb.33.1129

Reference yield:

: 85732-70-3
1-benzyl-4-hydroxy-4-(2-amino-5-chlorophenyl)piperidine

: 85732-25-8
1'-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>spiro<4H-3,1-benzoxazine-4,4'-piperidin>-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 0 °C

2: aq. NaOH / methanol

3: 85.5 percent / hydrogen, 1N HCl / 10percent Pd-C / H₂O; methanol / 20 h / 40 °C

4: 93.2 percent / TEA / ethanol / Ambient temperature

5: 91.9 percent / NaBH₄ / ethanol / 72 h / Ambient temperature

With pyridine; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; TEA; hydrogen; palladium on activated charcoal; In methanol; ethanol; water;
DOI:10.1248/cpb.33.1129