Boc-Lys(Z)-OSu

Base Information

• Chemical Name: Boc-Lys(Z)-OSu
• CAS No.: 34404-36-9
• Molecular Formula: C23H31 N3 O8
• Molecular Weight: 477.514
• Hs Code.: 29280000
• European Community (EC) Number: 251-999-7
• ChEMBL ID: CHEMBL3409486
• Nikkaji Number: J250.879F
• Mol file: 34404-36-9.mol

Synonyms:Boc-Lys(Z)-OSu;34404-36-9;MFCD00037915;Boc-Lys(Z)OSu;(S)-2,5-Dioxopyrrolidin-1-yl 6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoate;Boc-Lys(Z)-O Su;Boc-Lys-(Z)-OSu;SCHEMBL2803734;CHEMBL3409486;YWLICOCXPNQJPC-KRWDZBQOSA-N;AKOS015923314;AKOS016002281;CS-W008382;HY-W008382;DS-14203;NS00054918;F10856;A1-57572;J-019589;2,5-dioxopyrrolidin-1-yl N6-((benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysinate;(2,5-dioxopyrrolidin-1-yl) (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoate;2,5-Dioxopyrrolidin-1-yl (S)-6-((benzyloxycarbonyl)amino)-2-((tertbutoxycarbonyl)amino)hexanoate;2,5-Dioxopyrrolidin-1-yl(S)-6-((benzyloxycarbonyl)amino)-2-((tert-butoxycarbonyl)-amino)hexanoate;2,5-Dioxopyrrolidin-1-yl(S)-6-((benzyloxycarbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoate;2,5-Dioxopyrrolidin-1-yl(S)-6-((benzyloxycarbonyl)amino)-2-((tertbutoxycarbonyl)amino)hexanoate

Chemical Property of Boc-Lys(Z)-OSu

Chemical Property:

• Melting Point: 108-115 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 140.34000
• Density: 1.27g/cm³
• LogP: 3.30330
• Storage Temp.: −20°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 14
• Exact Mass: 477.21111496
• Heavy Atom Count: 34
• Complexity: 727

Purity/Quality:

97% ^*data from raw suppliers

Boc-Lys(Z)-OSu ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CCCCNC(=O)OCC1=CC=CC=C1)C(=O)ON2C(=O)CCC2=O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CCCCNC(=O)OCC1=CC=CC=C1)C(=O)ON2C(=O)CCC2=O
• Uses: Nepsilon-Benzyloxycarbonyl-Nalpha-Boc-L-lysine N-succinimidyl ester is a reactant involved in Cellular labeling and tumor MRI as a bimodal lipidic contrast agent, Synthesis of improved peptide prodrugs 5-ALA for photodynamic therapy, Design of high affinity peptide conjugates as markers for small peptide transporter PEPT1 (SLC15A1), Preparation of human growth hormone derivatives containing PEG groups, Enantiodivergent asymmetric cyclization and Solid-phase synthesis of peptide-cationic steroid conjugates for antibacterial screening. Reactant involved in:Cellular labeling and tumor MRI as a bimodal lipidic contrast agentSynthesis of improved peptide prodrugs 5-ALA for photodynamic therapyDesign of high affinity peptide conjugates as markers for small peptide transporter PEPT1 (SLC15A1)Preparation of human growth hormone derivatives containing PEG groupsEnantiodivergent asymmetric cyclizationSolid-phase synthesis of peptide-cationic steroid conjugates for antibacterial screening

Technology Process of Boc-Lys(Z)-OSu

There total 3 articles about Boc-Lys(Z)-OSu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Boc-Lys(Z)-OH (2389-45-9) → Boc-Lys(Z)-OSu (34404-36-9)

Guidance literature:

With dicyclohexyl-carbodiimide; 1.) EtOAc, 25 deg C, 3 h, 2.) Et₂O, overnight;

DOI:10.1021/jo00284a031

Reference yield: 85.0%

Boc-Lys(Z)-OH (2389-45-9) + 1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate (107960-02-1) → Boc-Lys(Z)-OSu (34404-36-9)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; acetonitrile; Ambient temperature;

DOI:10.1021/jo00388a005

Reference yield:

→ Boc-Lys(Z)-OSu (34404-36-9)

Guidance literature:

N^ε-Z-N^α-Boc-Lysin, N-Hydroxysuccinimid, DCC;

DOI:10.1007/BF00563819

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Boc-Lys(Z)-OH

1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate

Downstream raw materials:

Boc-Lys(Z)-Lys(Z)-OMe

N-(N^α-tert-butoxycarbonyl-N^ε-carbobenzoxy-L-lysyl)glycine ethyl ester

Boc-Lys(εZ)-Leu-OMe

Boc-Lys(N^e-Cbz)-Leu-Gly-OEt