Technology Process of Benzene, 2-(bromomethyl)-1-ethynyl-4-methoxy-
There total 6 articles about Benzene, 2-(bromomethyl)-1-ethynyl-4-methoxy- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,3,5-trimethyl-pyridine; triphenylphosphine dibromide 1:1 addition complex;
In
dichloromethane;
at 21 ℃;
for 5h;
DOI:10.1021/jo00139a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / pyridine / 1.) 0 degC, 15 min 2.) room temperature, 12 h
2: 68 percent / AlCl3 / CS2 / 0.5 h / Ambient temperature
3: 95 percent / PCl5 / POCl3 / 2 h / 45 - 50 °C
4: 92 percent / NaNH2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 degC 2.) 50 degC, 2 h
5: 94 percent / P(C6H5)3*Br2, collidine / CH2Cl2 / 5 h / Ambient temperature
With
pyridine; 2,3,5-trimethyl-pyridine; aluminium trichloride; phosphorus pentachloride; sodium amide; triphenylphosphine dibromide 1:1 addition complex;
In
tetrahydrofuran; carbon disulfide; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; trichlorophosphate;
DOI:10.1021/jo00183a018
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / AlCl3 / CS2 / 0.5 h / Ambient temperature
2: 95 percent / PCl5 / POCl3 / 2 h / 45 - 50 °C
3: 92 percent / NaNH2 / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 degC 2.) 50 degC, 2 h
4: 94 percent / P(C6H5)3*Br2, collidine / CH2Cl2 / 5 h / Ambient temperature
With
2,3,5-trimethyl-pyridine; aluminium trichloride; phosphorus pentachloride; sodium amide; triphenylphosphine dibromide 1:1 addition complex;
In
tetrahydrofuran; carbon disulfide; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; trichlorophosphate;
DOI:10.1021/jo00183a018
