Technology Process of Propanoic acid,
3-cyclohexylidene-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,
1-(2-phenylethyl)-3-butenyl ester
There total 3 articles about Propanoic acid,
3-cyclohexylidene-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,
1-(2-phenylethyl)-3-butenyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
t-bromocyclohexanecarbonyl bromide;
With
zinc;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
tert-butyl-dimethyl-[1-(1-phenethyl-but-3-enyloxy)-vinyloxy]-silane;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
DOI:10.1021/ja044736y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 92 percent / pyridine; 4-(dimethylamino)pyridine / CH2Cl2 / 5 h
2.1: diisopropylamine; n-butyllithium / hexane / 0.25 h / -78 °C
2.2: 96 percent / hexamethylphosphoramide / hexane / 0.5 h / -78 °C
3.1: zinc dust / tetrahydrofuran / 0.5 h / 0 °C
3.2: 68 percent / tetrahydrofuran / 16 h / 20 °C
With
pyridine; dmap; n-butyllithium; diisopropylamine; zinc;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja044736y
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diisopropylamine; n-butyllithium / hexane / 0.25 h / -78 °C
1.2: 96 percent / hexamethylphosphoramide / hexane / 0.5 h / -78 °C
2.1: zinc dust / tetrahydrofuran / 0.5 h / 0 °C
2.2: 68 percent / tetrahydrofuran / 16 h / 20 °C
With
n-butyllithium; diisopropylamine; zinc;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja044736y
