95999-38-5Relevant academic research and scientific papers
The synthetic protocol for α-bromocarbonyl compounds via brominations
Murata, Yumi,Takeuchi, Kentaro,Nishikata, Takashi
, p. 2726 - 2736 (2019/04/08)
α-Bromocarbonyl compound easily generates α-radicals in the presence of a proper initiator, such as copper salt. Recently, tertiary-alkylation reaction using α-bromocarbonyl compound as a tertiary alkyl source is recognized as one of the most important alkylation reactions. The reactions using α-bromocarbonyl compound are increasing, whereas synthetic methods for various functionalized α-bromocarbonyl compounds are not summarized. Generally, α-bromocarbonyl compounds can be synthesized from the corresponding carboxylic acids via α-bromo acid bromide, but the brominations of carboxylic acids are sometimes problematic. In this paper, we will report some technical information for a bromination and synthetic examples of representative α-bromocarbonyl compounds.
Asymmetric pericyclic cascade approach to spirocyclic oxindoles
Richmond, Edward,Duguet, Nicolas,Slawin, Alexandra M. Z.,Lebl, Tomas,Smith, Andrew D.
supporting information; experimental part, p. 2762 - 2765 (2012/07/14)
The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.
