tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate
• CAS No.: 821767-61-7
• Molecular Formula: C9H12N2O3
• Molecular Weight: 196.206
• Hs Code.: 2933199090
• Mol file: 821767-61-7.mol

Synonyms:1-BOC-4-FORMYLPYRAZOLE;TERT-BUTYL 4-FORMYL-1H-PYRAZOLE-1-CARBOXYLATE;4-formyl-pyrazole-1-carboxylic acid tert-butyl ester;

Chemical Property of tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate

Chemical Property:

• PSA: 61.19000
• LogP: 1.47880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl4-Formyl-1H-pyrazole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate

There total 3 articles about tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

di-tert-butyl dicarbonate (24424-99-5) + 1H-pyrazole-4-carbaldehyde (35344-95-7) → tert-butyl 4-formyl-1H-pyrazole-1-carboxylate (821767-61-7)

Guidance literature:

dmap; In acetonitrile; at 20 ℃; for 0.5h;

Reference yield: 74.0%

tert-butyl 4-(hydroxymethyl)-1H-pyrazole-1-carboxylate (199003-22-0) → tert-butyl 4-formyl-1H-pyrazole-1-carboxylate (821767-61-7)

Guidance literature:

With manganese(IV) oxide; magnesium sulfate; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-formyl-1H-pyrazole-1-carboxylate (821767-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / tetrahydrofuran / 1 h / 20 °C

2: magnesium sulfate; manganese(IV) oxide / dichloromethane / 16 h / 20 °C

With dmap; manganese(IV) oxide; magnesium sulfate; triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

tert-butyl 4-(hydroxymethyl)-1H-pyrazole-1-carboxylate

di-tert-butyl dicarbonate

1H-pyrazole-4-carbaldehyde

Downstream raw materials:

tert-butyl 4-((4-chloro-3-fluorophenyl)(4-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-2-oxopyridin-1(2H)-yl)methyl)-1H-pyrazole-1-carboxylate

tert-butyl 4-((4-chloro-3-fluorophenyl)(4-(2-(methylthio)pyrimidin-4-yl)-2-oxopyridin-1(2H)-yl)methyl)-1H-pyrazole-1-carboxylate

tert-butyl 4-(chloro(4-chloro-3-fluorophenyl)methyl)-1H-pyrazole-1-carboxylate

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