1-[4-AMino-7-(3-tert-butyldiMethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidine

Base Information

Chemical Name:1-[4-AMino-7-(3-tert-butyldiMethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidine
CAS No.:821794-84-7
Molecular Formula:C22H32N4OSi
Molecular Weight:396.608
Hs Code.:
Mol file:821794-84-7.mol

Synonyms:1-[4-Amino-7-(3-tert-butyldimethylsilyloxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine;

Suppliers and Price of 1-[4-AMino-7-(3-tert-butyldiMethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-[4-Amino-7-(3-tert-butyldimethylsilyloxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine
250mg
$ 1320.00

Medical Isotopes, Inc.
1-[4-Amino-7-(3-tert-butyldimethylsilyloxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine
25 mg
$ 650.00

Chemenu
7-(3-((Tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 95%+
1g
$ 992.00

Total 3 raw suppliers

Chemical Property of 1-[4-AMino-7-(3-tert-butyldiMethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidine

Chemical Property:

Boiling Point:537.1±50.0 °C(Predicted)
PKA:5.83±0.30(Predicted)
PSA：65.96000
Density:1.08±0.1 g/cm3(Predicted)
LogP:5.98200
Solubility.:Chloroform, Dichloromethane, Dimethyl Formamide, Ethyl Acetate

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-[4-Amino-7-(3-tert-butyldimethylsilyloxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Reactant in the preparation of serine/threonine kinase inhibitors.

Technology Process of 1-[4-AMino-7-(3-tert-butyldiMethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidine

There total 4 articles about 1-[4-AMino-7-(3-tert-butyldiMethylsilyloxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 78878-05-4
1-iodo-3-(tert-butyldimethylsilyloxy)propane

: 121405-36-5
5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 821794-84-7
7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: 5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

1-iodo-3-(tert-butyldimethylsilyloxy)propane; In N,N-dimethyl-formamide; for 4h;

Reference yield: 61.0%

: C₂₄H₃₅N₃O₂Si

: 821794-84-7
7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: With ammonia; In methanol; at 20 - 50 ℃; for 96.5h; Cooling with dry ice/MeOH bath; Sealed-tube;

Reference yield:

: 1307896-57-6
methyl N-3-cyano-4-p-tolyl-1H-pyrrol-2-ylformimidate

: 821794-84-7
7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol / 4 h / 20 °C

2.1: sodium methylate / methanol / 3 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h

With ammonia; sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;