6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS No.:821794-85-8
Molecular Formula:C22H31BrN4OSi
Molecular Weight:475.504
Hs Code.:
DSSTox Substance ID:DTXSID701107153
Mol file:821794-85-8.mol

Synonyms:821794-85-8;6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-bromo-7-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5-(4-methylphenyl)-;6-bromo-7-[3-[tert-butyl(dimethyl)silyl]oxypropyl]-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;6-Bromo-7-[3-(tert-butyldimethylsilyloxy)propyl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine;SCHEMBL1896444;VGTJTCPTXXDTEL-UHFFFAOYSA-N;DTXSID701107153;CS-M1785;6-bromo-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;6-bromo-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo [2,3-d]pyrimidin-4-amine;6-Bromo-7-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Suppliers and Price of 6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 95%+
100mg
$ 2568.00

Total 6 raw suppliers

Chemical Property of 6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Chemical Property:

PSA：65.96000
LogP:6.74450
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:474.14505
Heavy Atom Count:29
Complexity:535

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=C(N(C3=NC=NC(=C23)N)CCCO[Si](C)(C)C(C)(C)C)Br

Technology Process of 6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

There total 5 articles about 6-Bromo-7-(3-((tert-butyldimethylsilyl)oxy)propyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 821794-84-7
7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 821794-85-8
6-bromo-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 121405-36-5
5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 821794-85-8
6-bromo-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 4 h

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

With N-Bromosuccinimide; sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

: 1307896-57-6
methyl N-3-cyano-4-p-tolyl-1H-pyrrol-2-ylformimidate

: 821794-85-8
6-bromo-7-(3-(tert-butyldimethylsilyloxy)propyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / methanol / 4 h / 20 °C

2.1: sodium methylate / methanol / 3 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

With N-Bromosuccinimide; ammonia; sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;