4-[(1S,3aα,6aα)-4α-(1,3-Benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1β-yl]-2-methoxyphenol

Base Information

Chemical Name:4-[(1S,3aα,6aα)-4α-(1,3-Benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1β-yl]-2-methoxyphenol
CAS No.:28115-67-5
Molecular Formula:C₂₀H₂₀O₆
Molecular Weight:356.375
Hs Code.:
Mol file:28115-67-5.mol

Synonyms:Phenol,2-methoxy-4-[tetrahydro-4-[3,4-(methylenedioxy)phenyl]-1H,3H-furo[3,4-c]furan-1-yl]-(8CI); Phenol,4-[4-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxy-,[1S-(1a,3ab,4b,6ab)]-; 1H,3H-Furo[3,4-c]furan,phenol deriv.; (-)-Pluviatilol; Pluviatilol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(1S,3aα,6aα)-4α-(1,3-Benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1β-yl]-2-methoxyphenol

Chemical Property:

PSA：66.38000
LogP:3.20470

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[(1S,3aα,6aα)-4α-(1,3-Benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1β-yl]-2-methoxyphenol

There total 17 articles about 4-[(1S,3aα,6aα)-4α-(1,3-Benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1β-yl]-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 651779-93-0
(1R,2R,5R,6S)-2-(3,4-methylenedioxy)phenyl-6-(4-methanesulfonyloxy-3-methoxy)phenyl-3,7-dioxabicyclo[3.3.0]octane

: 28115-67-5,52151-92-5,54983-95-8,54983-96-9,62935-82-4,105661-98-1,110268-41-2,111407-29-5,92620-81-0
Pluviatilol

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; methanol; water; at 50 ℃; for 40h;
DOI:10.1021/jo035365r

Reference yield: 81.0%

: 105602-51-5
(+/-)-benzylpluviatilol

: 28115-67-5,52151-92-5,54983-95-8,54983-96-9,62935-82-4,92620-81-0,105661-98-1,110268-41-2,111407-29-5
(+/-)-pluviatilol

Guidance literature:: With hydrogen;
DOI:10.1016/S0040-4039(00)85023-6

Reference yield:

: 52200-05-2
4-methanesulfonyloxy-3-methoxybenzaldehyde

: 28115-67-5,52151-92-5,54983-95-8,54983-96-9,62935-82-4,105661-98-1,110268-41-2,111407-29-5,92620-81-0
Pluviatilol

Guidance literature:: Multi-step reaction with 10 steps

1: tetrahydrofuran / -60 - -10 °C

2: 39 percent / Novozyme 435 / 17 h / 40 °C

3: 92 percent / xylene / 0.25 h / 150 °C

4: Mn(OAc)3*2H₂O; Cu(OAc)2; KOAc / acetic acid / 0.25 h / 70 °C

5: 54 percent / 2,6-di-tert-butylpyridine; Mg(ClO₄)2 / 2.5 h / 120 °C

6: 88 percent / triflic anhydride; tetrabutylammonium bromide; sodium azide / sodium hydroxide / hexane; acetonitrile; H₂O / 0.5 h / 0 °C

7: 83 percent / dirhodium tetraacetate / CH₂Cl₂ / 3 h / 20 °C

8: 13 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / 0 °C

9: 76 percent / 4-(N,N-dimethylamino)pyridine; triethylamine; mesyl chloride / CH₂Cl₂ / 49 h

10: 90 percent / potassium hydroxide / dioxane; methanol; H₂O / 40 h / 50 °C

With dmap; dirhodium tetraacetate; potassium hydroxide; lithium aluminium tetrahydride; sodium azide; 2,6-di-tert-butyl-pyridine; magnesium(II) perchlorate; copper diacetate; novozyme 435; trifluoromethylsulfonic anhydride; tetrabutylammomium bromide; potassium acetate; manganese triacetate; methanesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; acetic acid; acetonitrile; xylene;
DOI:10.1021/jo035365r