4-Formyl-2-methoxyphenyl methanesulfonate

Base Information

• Chemical Name: 4-Formyl-2-methoxyphenyl methanesulfonate
• CAS No.: 52200-05-2
• Molecular Formula: C9H10O5S
• Molecular Weight: 230.241
• European Community (EC) Number: 651-804-9
• DSSTox Substance ID: DTXSID40394657
• Nikkaji Number: J1.400.507B
• Wikidata: Q82194182
• Mol file: 52200-05-2.mol

Synonyms:4-formyl-2-methoxyphenyl methanesulfonate;52200-05-2;(4-formyl-2-methoxyphenyl) methanesulfonate;Methanesulfonic acid 4-formyl-2-methoxy-phenyl ester;SCHEMBL6132027;DTXSID40394657;BDBM237298;STL290872;AKOS000296998;4-Formyl-2-methoxyphenyl methanesulfonate (15)

Chemical Property of 4-Formyl-2-methoxyphenyl methanesulfonate

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 230.02489459
• Heavy Atom Count: 15
• Complexity: 305

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C=O)OS(=O)(=O)C

Technology Process of 4-Formyl-2-methoxyphenyl methanesulfonate

There total 5 articles about 4-Formyl-2-methoxyphenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

p-(hydroxymethyl)-2-methoxyphenyl methanesulfonate → 4-methanesulfonyloxy-3-methoxybenzaldehyde (52200-05-2)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tert-butyl alcohol; at 25 ℃; pH=11.5; aq. sodium carbonate/bicarbonate buffer; Electrolysis;

DOI:10.1002/cssc.201100601

Reference yield: 62.0%

vanillin (121-33-5,8014-42-4) + methanesulfonyl chloride (124-63-0) → 4-methanesulfonyloxy-3-methoxybenzaldehyde (52200-05-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.oprd.6b00314

Reference yield:

N-ethanoyl-methanesulfonamide (81005-29-0) + vanillin (121-33-5,8014-42-4) → 4-methanesulfonyloxy-3-methoxybenzaldehyde (52200-05-2)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; Reflux;

DOI:10.1016/j.ejmech.2017.02.032

upstream raw materials:

diazomethane

vanillin

methanesulfonyl chloride

N-ethanoyl-methanesulfonamide

Downstream raw materials:

3-Methoxy-4-phenylsulfanyl-benzaldehyde

methanesulfonic acid 4-[cyano-(3,4-dimethoxy-benzylamino)-methyl]-2-methoxy-phenyl ester

methanesulfonic acid 4-(6,7-dimethoxy-4-oxo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-2-methoxy-phenyl ester

[4-hydroxy-3-(4-methanesulfonyloxy-3-methoxy-phenyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetic acid ethyl ester