Pyridine, 5-chloro-4-iodo-2-(trifluoromethyl)-

Base Information

• Chemical Name: Pyridine, 5-chloro-4-iodo-2-(trifluoromethyl)-
• CAS No.: 823221-95-0
• Molecular Formula: C6H2ClF3IN
• Molecular Weight: 307.441
• Mol file: 823221-95-0.mol

Synonyms:Pyridine,5-chloro-4-iodo-2-(trifluoromethyl);

Chemical Property of Pyridine, 5-chloro-4-iodo-2-(trifluoromethyl)-

Chemical Property:

• PSA: 12.89000
• LogP: 3.35840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-4-iodo-2-(trifluoromethyl)pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 5-chloro-4-iodo-2-(trifluoromethyl)-

There total 3 articles about Pyridine, 5-chloro-4-iodo-2-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-chloro-2-(trifluoromethyl)pyridine (349-94-0) → 5-chloro-4-iodo-2-(trifluoromethyl)pyridine (823221-95-0)

Guidance literature:

5-chloro-2-(trifluoromethyl)pyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

With iodine; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2004.09.106

Reference yield:

5-chloro-2-iodo-pyridine (244221-57-6) → 5-chloro-4-iodo-2-(trifluoromethyl)pyridine (823221-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 72 percent / potassium fluoride; cuprous iodide; N-methylpyrrolidinone

2.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -75 °C

2.2: 87 percent / iodine / hexane; tetrahydrofuran

With 1-methyl-pyrrolidin-2-one; potassium fluoride; copper(l) iodide; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2004.09.106

Reference yield:

2-Bromo-5-chloro-pyridine (40473-01-6) → 5-chloro-4-iodo-2-(trifluoromethyl)pyridine (823221-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 87 percent / sodium iodide; chlorotrimethylsilane / various solvent(s) / 6 h / Heating

2.1: 72 percent / potassium fluoride; cuprous iodide; N-methylpyrrolidinone

3.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -75 °C

3.2: 87 percent / iodine / hexane; tetrahydrofuran

With 1-methyl-pyrrolidin-2-one; potassium fluoride; copper(l) iodide; chloro-trimethyl-silane; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2004.09.106

upstream raw materials:

5-chloro-2-(trifluoromethyl)pyridine

2-Bromo-5-chloro-pyridine

5-chloro-2-iodo-pyridine