349-94-0

Basic information

• Product Name: 5-Chloro-2-(trifluoromethyl)pyridine
• Synonyms: 5-Chloro-2-(trifluoromethyl)pyridine;-Chloro-2-(trifluoroMethyl)pyridine;5-Chloro-alpha,alpha,alpha-trifluoro-2-picoline
• CAS NO: 349-94-0
• Molecular Formula: C₆H₃ClF₃N
• Molecular Weight: 181.54
• Product Categories: API intermediates;Fluorine series;organic building block
• Mol File: 349-94-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 35-37°C
• Boiling Point: 146 °C at 760 mmHg
• Flash Point: 54℃
• Appearance: /
• Density: 1.416 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.73±0.22(Predicted)
• CAS DataBase Reference: 5-Chloro-2-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-(trifluoromethyl)pyridine(349-94-0)
• EPA Substance Registry System: 5-Chloro-2-(trifluoromethyl)pyridine(349-94-0)

Safety Data

• Hazard Codes: Xi,T,F
• Statements: 11-25-36/37/38
• Safety Statements: 26-45
• RIDADR: 2926
• WGK Germany: 3
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• PackingGroup: Ⅲ
• Hazardous Substances Data: 349-94-0(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-(trifluoromethyl)pyridine is a chemical compound with the molecular formula C6H3ClF3N. It is a pyridine derivative with a chlorine atom and a trifluoromethyl group attached to the second and fifth carbon atoms, respectively. 5-Chloro-2-(trifluoromethyl)pyridine is often used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is a highly reactive and versatile compound with potential applications in various fields of organic chemistry. The presence of the trifluoromethyl group makes it particularly valuable in medicinal chemistry, as this functional group is known to enhance the biological activity and metabolic stability of pharmaceutical compounds. Overall, 5-Chloro-2-(trifluoromethyl)pyridine is a valuable and versatile chemical compound with wide-ranging applications in the synthesis of biologically active molecules.

Upstream product

• 89719-90-4 2,3-dichloro-6-(trifluoromethyl)pyridine 
• 51492-01-4 2,3-dichloro-6-(trichloromethyl)pyridine 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 244221-57-6 5-chloro-2-iodo-pyridine 
• 109-06-8 α-picoline 

Downstream Products

• 1030632-94-0 3-ethyl-6-trifluoromethyl pyridine 
• 765298-04-2 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile 
• 1214370-35-0 5-phenyl-2-(trifluoromethyl)pyridine 
• 823221-95-0 5-chloro-4-iodo-2-(trifluoromethyl)pyridine 

Relevant articles and documents

Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A bottom-Up Approach

MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.

CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2

The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).