Technology Process of 6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione,
1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-4-(2-hydroxyethyl)-5-methyl
-, (1R,4R,5S)-
There total 103 articles about 6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione,
1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-4-(2-hydroxyethyl)-5-methyl
-, (1R,4R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine;
In
dichloromethane;
at 20 ℃;
for 16.1667h;
- Guidance literature:
-
(3R,4S,5R)-5-benzyloxycarbonyl-5-((S)-((S)-cyclohex-2-enyl)hydroxymethyl)-4-hydroxy-3-(2-hydroxyethyl)-4-methyl-2-pyrrolidone;
With
ammonia; sodium;
In
tetrahydrofuran; water; tert-butyl alcohol;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine;
In
dichloromethane; toluene;
at 20 ℃;
for 14h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol200886j
- Guidance literature:
-
(2R,3S,4R)-2-((S)-(S)-Cyclohex-2-enyl-hydroxy-methyl)-3-hydroxy-4-(2-hydroxy-ethyl)-3-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester;
With
[Me2AlTeMe]2;
In
toluene;
at 20 ℃;
for 8h;
With
hydrogenchloride; water;
In
ethyl acetate; toluene;
at 20 ℃;
for 1h;
With
pyridine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
In
dichloromethane;
at 20 ℃;
for 3h;
DOI:10.1002/anie.200801967
