Chemical Property of Marizomib
Chemical Property:
- Boiling Point:547.0±50.0 °C(Predicted)
- PKA:13.10±0.20(Predicted)
- PSA：79.12000
- Density:1.348±0.06 g/cm3(Predicted)
- LogP:1.40870
- Storage Temp.:-20°C
- Solubility.:Soluble in DMSO
- XLogP3:1.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:4
- Exact Mass:313.1080858
- Heavy Atom Count:21
- Complexity:508
- Purity/Quality:
-
99%, *data from raw suppliers
Salinosporamide A *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC12C(C(=O)NC1(C(=O)O2)C(C3CCCC=C3)O)CCCl
- Isomeric SMILES:C[C@]12[C@H](C(=O)N[C@]1(C(=O)O2)[C@H]([C@H]3CCCC=C3)O)CCCl
- Recent ClinicalTrials:A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma
- Recent EU Clinical Trials:A phase III trial of marizomib in combination with standard temozolomide-based radiochemotherapy versus standard temozolomide-based radiochemotherapy alone in patients with newly diagnosed glioblastoma - MIRAGE
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Uses
Marizomib has been used as a proteasome inhibitor:to study its effects on glioblastoma cell linesto analyze its effects on the aging of killifish brainto test its effect on protein kinase B (PKB/AKT) levels in multiple myeloma cells
