4-(2,3-Dimethoxyphenyl)-1-methylpiperidin-4-ol

Base Information

• Chemical Name: 4-(2,3-Dimethoxyphenyl)-1-methylpiperidin-4-ol
• CAS No.: 82359-62-4
• Molecular Formula: C14H21NO3
• Molecular Weight: 251.326
• DSSTox Substance ID: DTXSID20532090
• Wikidata: Q82404431
• Mol file: 82359-62-4.mol

Synonyms:4-(2,3-Dimethoxyphenyl)-1-methylpiperidin-4-ol;82359-62-4;SCHEMBL2782958;DTXSID20532090

Chemical Property of 4-(2,3-Dimethoxyphenyl)-1-methylpiperidin-4-ol

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 251.15214353
• Heavy Atom Count: 18
• Complexity: 264

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(CC1)(C2=C(C(=CC=C2)OC)OC)O

Technology Process of 4-(2,3-Dimethoxyphenyl)-1-methylpiperidin-4-ol

There total 2 articles about 4-(2,3-Dimethoxyphenyl)-1-methylpiperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-Methyl-4-piperidone (1445-73-4) + 3-lithio-1,2-dimethoxybenzene (2785-95-7) → 1-methyl-4-hydroxy-4-(2,3-dimethoxyphenyl)piperidine (82359-62-4)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1016/S0040-4039(00)86810-0

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + 1,2-dimethoxybenzene (91-16-7) → 1-methyl-4-hydroxy-4-(2,3-dimethoxyphenyl)piperidine (82359-62-4)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) ether, 20 deg C, 18 h, 2.) ether;

DOI:10.1021/jm00155a026

Reference yield: 95.0%

1-methyl-4-hydroxy-4-(2,3-dimethoxyphenyl)piperidine (82359-62-4) → 4-(2,3-Dimethoxyphenyl)-1,2,3,6-tetrahydro-1-methyl-pyridine (82359-63-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 110 ℃; for 2h;

DOI:10.1016/S0040-4039(00)86810-0

upstream raw materials:

1-Methyl-4-piperidone

1,2-dimethoxybenzene

3-lithio-1,2-dimethoxybenzene

Downstream raw materials:

4-(2,3-Dimethoxyphenyl)-1,2,3,6-tetrahydro-1-methyl-pyridine

(+/-)-1-methyl-4-(2,3-dimethoxyphenyl)-4-(3-propenyl)-1,4,5,6-tetrahydropyridine

(+/-)-2-methyl-4-bromo-5-(2,3-dimethoxyphenyl)-2-azabicyclo<3.3.1>non-3-ene

(+/-)-2-methyl-4-bromo-5-(2,3-dimethoxyphenyl)-2-azabicyclo<3.3.1>nonane