tert-butyl N-[(2R)-4-bromo-3-oxo-1-phenylbutan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl N-[(2R)-4-bromo-3-oxo-1-phenylbutan-2-yl]carbamate
CAS No.:823806-88-8
Molecular Formula:C15H20BrNO3
Molecular Weight:342.233
Hs Code.:
European Community (EC) Number:871-271-8

Synonyms:tert-butyl N-[(2R)-4-bromo-3-oxo-1-phenylbutan-2-yl]carbamate;823806-88-8;EN300-7539196

Suppliers and Price of tert-butyl N-[(2R)-4-bromo-3-oxo-1-phenylbutan-2-yl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of tert-butyl N-[(2R)-4-bromo-3-oxo-1-phenylbutan-2-yl]carbamate

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:341.06266
Heavy Atom Count:20
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)C(=O)CBr
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H](CC1=CC=CC=C1)C(=O)CBr

Technology Process of tert-butyl N-[(2R)-4-bromo-3-oxo-1-phenylbutan-2-yl]carbamate

There total 1 articles about tert-butyl N-[(2R)-4-bromo-3-oxo-1-phenylbutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 18942-49-9
Boc-D-Phe-OH

: 823806-88-8
(1-benzyl-3-bromo-2-oxo-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Boc-D-Phe-OH; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 ℃; for 0.0833333h;

diazomethane; In tetrahydrofuran; at 0 ℃; for 2h;

With hydrogen bromide; In tetrahydrofuran;
DOI:10.1021/jm049566e

Reference yield:

: 823806-88-8
(1-benzyl-3-bromo-2-oxo-propyl)-carbamic acid tert-butyl ester

: 823806-89-9
((1R,2R)-1-Benzyl-3-bromo-2-hydroxy-propyl)-carbamic acid tert-butyl ester

Guidance literature:: With dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 1h;
DOI:10.1021/jm049566e

Reference yield:

: 823806-88-8
(1-benzyl-3-bromo-2-oxo-propyl)-carbamic acid tert-butyl ester

: 156474-21-4
tert-butyl [(2R,3R)]-(-)-(1-oxiranyl-2-phenylethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-2-methyl-CBS-oxazaborolidine; boranemethyl sulfide / toluene; tetrahydrofuran / 1 h / 20 °C

2: NaOMe / methanol / 1.5 h

With dimethylsulfide borane complex; sodium methylate; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm049566e