Technology Process of Glycine,
N-[[2,3,4-trimethoxy-6-[[(4-methoxyphenyl)methyl]thio]phenyl]methyl]-,
1,1-dimethylethyl ester
There total 4 articles about Glycine,
N-[[2,3,4-trimethoxy-6-[[(4-methoxyphenyl)methyl]thio]phenyl]methyl]-,
1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride; acetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1021/ol048145o
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 89 percent / POCl3 / CH2Cl2 / 5 h / 150 °C
2: 93 percent / NaBH(OAc)3; aq. AcOH / CH2Cl2 / 1 h / 20 °C
With
sodium tris(acetoxy)borohydride; acetic acid; trichlorophosphate;
In
dichloromethane;
1: Vilsmeyer formylation;
DOI:10.1021/ol048145o
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. K3PO4 / toluene / 0 - 20 °C
2: 85 percent / Pd(OAc)2; (R)-(+)-BINAP; Et3N / dimethylformamide / 0.33 h / 150 °C / microwave irradiation
3: 89 percent / POCl3 / CH2Cl2 / 5 h / 150 °C
4: 93 percent / NaBH(OAc)3; aq. AcOH / CH2Cl2 / 1 h / 20 °C
With
palladium diacetate; potassium phosphate; sodium tris(acetoxy)borohydride; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; trichlorophosphate;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
3: Vilsmeyer formylation;
DOI:10.1021/ol048145o
