2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid

Base Information

• Chemical Name: 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid
• CAS No.: 823829-31-8
• Molecular Formula: C₃₁H₃₁NO₄S
• Molecular Weight: 513.657
• Mol file: 823829-31-8.mol

Synonyms:Glycine,N-[1-(2,4-dimethoxyphenyl)-2-[(triphenylmethyl)thio]ethyl];

Chemical Property of 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid

Chemical Property:

• Boiling Point: 682.1±55.0 °C(Predicted)
• PKA: 2.21±0.10(Predicted)
• PSA: 93.09000
• Density: 1.206±0.06 g/cm3(Predicted)
• LogP: 6.53530

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid

There total 4 articles about 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(S-trityl)mercapto-2’,4’-dimethoxyacetophenone (823829-27-2) + glycine (56-40-6,18875-39-3,25718-94-9) → N-(1-(2,4-dimethoxyphenyl)-2-S-tritylmercapto)ethylglycine (823829-31-8)

Guidance literature:

With sodium cyanoborohydride; In methanol; for 72h; Reflux;

DOI:10.1039/c4cc03721a

Reference yield:

2-Bromo-2',4'-dimethoxyacetophenone (60965-26-6) → N-(1-(2,4-dimethoxyphenyl)-2-S-tritylmercapto)ethylglycine (823829-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / DIPEA / dimethylformamide / 2 h / 20 °C

2: 58 percent / NaBH₃CN / methanol / Heating

With sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ol048145o

Reference yield:

triphenylmethanethiol (3695-77-0) → N-(1-(2,4-dimethoxyphenyl)-2-S-tritylmercapto)ethylglycine (823829-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / DIPEA / dimethylformamide / 2 h / 20 °C

2: 58 percent / NaBH₃CN / methanol / Heating

With sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ol048145o

upstream raw materials:

2-(S-trityl)mercapto-2’,4’-dimethoxyacetophenone

glycine

2-Bromo-2',4'-dimethoxyacetophenone

triphenylmethanethiol