Pyrimidine, 1,4,5,6-tetrahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl-

Base Information

Chemical Name:Pyrimidine, 1,4,5,6-tetrahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl-
CAS No.:824390-95-6
Molecular Formula:C18H20N2O2S
Molecular Weight:328.435
Hs Code.:

Synonyms:2-methyl-4-phenyl-1-tosyl-1,4,5,6-tetrahydropyrimidine;2-Methyl-4-phenyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydro-pyrimidine;

Suppliers and Price of Pyrimidine, 1,4,5,6-tetrahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrimidine, 1,4,5,6-tetrahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl-

Chemical Property:

PSA：58.12000
LogP:4.00340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 1,4,5,6-tetrahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl-

There total 6 articles about Pyrimidine, 1,4,5,6-tetrahydro-2-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 38455-36-6
N-tosyl-2-phenylazetidine

: 75-05-8,26809-02-9
acetonitrile

: 824390-95-6
2-methyl-4-phenyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyrimidine

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); at 80 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1016/j.tetlet.2008.12.035

Reference yield:

: 51608-60-7
N-(benzylidene)-p-methylbenzenesulfonamide

: 824390-95-6
2-methyl-4-phenyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 100 percent / tetrahydrofuran / 2 h / -78 °C

2.1: 100 percent / LAH / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: TsCl; KOH / tetrahydrofuran / 0.5 h / Heating

4.1: 76 percent / Zn(OTf)2 / 1.5 h / 80 °C

With potassium hydroxide; lithium aluminium tetrahydride; p-toluenesulfonyl chloride; lithium diisopropyl amide; zinc trifluoromethanesulfonate; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2006.05.058

Reference yield:

: 155495-87-7
tert-butyl 3-(4-toluenesulfonamido)-3-phenylpropanoate

: 824390-95-6
2-methyl-4-phenyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / LAH / tetrahydrofuran / 1 h / 0 - 20 °C

2: TsCl; KOH / tetrahydrofuran / 0.5 h / Heating

3: 76 percent / Zn(OTf)2 / 1.5 h / 80 °C

With potassium hydroxide; lithium aluminium tetrahydride; p-toluenesulfonyl chloride; zinc trifluoromethanesulfonate; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2006.05.058