Azetidine, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-

Base Information

• Chemical Name: Azetidine, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-
• CAS No.: 38455-36-6
• Molecular Formula: C16H17NO2S
• Molecular Weight: 287.382
• Hs Code.: 2933990090
• Mol file: 38455-36-6.mol

Synonyms:N-tosyl-2-phenylazetidine;2-phenyl-N-tosylazetidine;Azetidine,1-[(4-methylphenyl)sulfonyl]-2-phenyl;2-phenyl-1-tosyl-azetidine;2-Phenyl-N-(p-toluenesulphonyl)-azetidine;1-((4-Methylphenyl)sulfonyl)-2-phenylazetidine;2-phenyl-1-(toluene-4-sulfonyl)-azetidine;

Chemical Property of Azetidine, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-

Chemical Property:

• PSA: 45.76000
• LogP: 4.14940

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Azetidine, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-

There total 17 articles about Azetidine, 1-[(4-methylphenyl)sulfonyl]-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(+/-)-3-phenyl-3-(toluene-4-sulfonylamino)-propionic acid (155496-06-3) → N-tosyl-2-phenylazetidine (38455-36-6)

Guidance literature:

With p-toluenesulfonyl chloride; potassium hydroxide; In tetrahydrofuran; at 20 ℃; Reflux;

DOI:10.1039/c5ob01140j

Reference yield: 96.0%

N-(3-hydroxy-1-phenylpropyl)-4-methylbenzenesulfonamide (170304-99-1) → N-tosyl-2-phenylazetidine (38455-36-6)

Guidance literature:

With p-toluenesulfonyl chloride; potassium hydroxide; In tetrahydrofuran; Reflux; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.202100195

Reference yield: 75.0%

4-methyl-N-(1-phenyl-allyl)-benzenesulfonamide (58567-43-4) → N-tosyl-2-phenylazetidine (38455-36-6) + trans-2-methyl-3-phenyl-1-tosylaziridine + cis-2-methyl-1-[(4-methylphenyl)sulfonyl]-3-phenylaziridine

Guidance literature:

4-methyl-N-(1-phenyl-allyl)-benzenesulfonamide; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 12h;

With sodium hydroxide; ethanol; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 2h;

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ol048161l

upstream raw materials:

N-(p-tolylsulfonyl)-2-phenylaziridine

dimethylsulfoxonium methylide

2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine

N-(benzylidene)-p-methylbenzenesulfonamide

Downstream raw materials:

N-(3-hydroxy-3-phenylpropyl)-4-methyl-benzenesulfonamide

4-methyl-N-[(2E)-3-phenylprop-2-en-1-yl]benzene-1-sulfonamide