3,4-Dihydroxybenzoic acid 11-hydroxy-12-oxoabieta-5,7,9(11),13-tetraene-2α-yl ester

Base Information

Chemical Name:3,4-Dihydroxybenzoic acid 11-hydroxy-12-oxoabieta-5,7,9(11),13-tetraene-2α-yl ester
CAS No.:66656-58-4
Molecular Formula:C27H30O6
Molecular Weight:450.52
Hs Code.:

Synonyms:Parvifloron F;3,4-Dihydroxy-benzoic acid (3S,4aS)-5-hydroxy-7-isopropyl-1,1,4a-trimethyl-6-oxo-1,2,3,4,4a,6-hexahydro-phenanthren-3-yl ester;

Suppliers and Price of 3,4-Dihydroxybenzoic acid 11-hydroxy-12-oxoabieta-5,7,9(11),13-tetraene-2α-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Dihydroxybenzoic acid 11-hydroxy-12-oxoabieta-5,7,9(11),13-tetraene-2α-yl ester

Chemical Property:

PSA：104.06000
LogP:5.29310

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydroxybenzoic acid 11-hydroxy-12-oxoabieta-5,7,9(11),13-tetraene-2α-yl ester

There total 4 articles about 3,4-Dihydroxybenzoic acid 11-hydroxy-12-oxoabieta-5,7,9(11),13-tetraene-2α-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 4-({[(3S,4aS)-5-hydroxy-7-isopropyl-1,1,4a-trimethyl-6-oxo-1,2,3,4,4a,6-hexahydrophenanthren-3-yl]oxy}carbonyl)-1,2-phenylene dibenzoate

: 66656-58-4
(3S,4aS)-5-hydroxy-7-isopropyl-1,1,4a-trimethyl-6-oxo-1,2,3,4,4a,6-hexahydrophenanthren-3-yl 3,4-dihydroxybenzoate

Guidance literature:: With N-butylamine; In benzene; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b03763

Reference yield:

: (4bS,6S)-6-hydroxy-2-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a-hexahydrophenanthrene-3,4-dione

: 66656-58-4
(3S,4aS)-5-hydroxy-7-isopropyl-1,1,4a-trimethyl-6-oxo-1,2,3,4,4a,6-hexahydrophenanthren-3-yl 3,4-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 5 h / Reflux; Inert atmosphere

2.1: triethylamine; dmap; 2-methyl-6-nitrobenzoic anhydride / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

3.1: N-butylamine / benzene / 2 h / 20 °C / Inert atmosphere

With dmap; 2-methyl-6-nitrobenzoic anhydride; N-butylamine; triethylamine; In dichloromethane; toluene; benzene;
DOI:10.1021/acs.orglett.7b03763

Reference yield:

: 99-50-3
3,4-Dihydroxybenzoic acid

: 66656-58-4
(3S,4aS)-5-hydroxy-7-isopropyl-1,1,4a-trimethyl-6-oxo-1,2,3,4,4a,6-hexahydrophenanthren-3-yl 3,4-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 2 h / Reflux

2.1: triethylamine; dmap; 2-methyl-6-nitrobenzoic anhydride / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

3.1: N-butylamine / benzene / 2 h / 20 °C / Inert atmosphere

With pyridine; dmap; 2-methyl-6-nitrobenzoic anhydride; N-butylamine; triethylamine; In dichloromethane; benzene;
DOI:10.1021/acs.orglett.7b03763