2-Propenamide, 3-(2,4-dimethoxy-6-methyl-5-pyrimidinyl)-N-(2-hydroxy-1-((((methylthio)methyl)thio)methyl)ethyl)-, (E)-(+-)-

Base Information

Chemical Name:2-Propenamide, 3-(2,4-dimethoxy-6-methyl-5-pyrimidinyl)-N-(2-hydroxy-1-((((methylthio)methyl)thio)methyl)ethyl)-, (E)-(+-)-
CAS No.:119840-23-2
Molecular Formula:C₁₅H₂₃N₃O₄S₂
Molecular Weight:373.497
Hs Code.:

Synonyms:BRN 5618676;2-Propenamide, 3-(2,4-dimethoxy-6-methyl-5-pyrimidinyl)-N-(2-hydroxy-1-((((methylthio)methyl)thio)methyl)ethyl)-, (E)-(+-)-;119840-23-2;C15H23N3O4S2;C15-H23-N3-O4-S2;LS-123353

Suppliers and Price of 2-Propenamide, 3-(2,4-dimethoxy-6-methyl-5-pyrimidinyl)-N-(2-hydroxy-1-((((methylthio)methyl)thio)methyl)ethyl)-, (E)-(+-)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 1 raw suppliers

Chemical Property of 2-Propenamide, 3-(2,4-dimethoxy-6-methyl-5-pyrimidinyl)-N-(2-hydroxy-1-((((methylthio)methyl)thio)methyl)ethyl)-, (E)-(+-)-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.264g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:10
Exact Mass:373.11299857
Heavy Atom Count:24
Complexity:401

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NC(=N1)OC)OC)C=CC(=O)NC(CO)CSCSC
Isomeric SMILES:CC1=C(C(=NC(=N1)OC)OC)/C=C/C(=O)NC(CO)CSCSC

Technology Process of 2-Propenamide, 3-(2,4-dimethoxy-6-methyl-5-pyrimidinyl)-N-(2-hydroxy-1-((((methylthio)methyl)thio)methyl)ethyl)-, (E)-(+-)-

There total 4 articles about 2-Propenamide, 3-(2,4-dimethoxy-6-methyl-5-pyrimidinyl)-N-(2-hydroxy-1-((((methylthio)methyl)thio)methyl)ethyl)-, (E)-(+-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%

: 119840-22-1
2-[(E)-3-(2,4-Dimethoxy-6-methyl-pyrimidin-5-yl)-acryloylamino]-3-methylsulfanylmethylsulfanyl-propionic acid methyl ester

: 119840-23-2
(E)-3-(2,4-Dimethoxy-6-methyl-pyrimidin-5-yl)-N-(1-hydroxymethyl-2-methylsulfanylmethylsulfanyl-ethyl)-acrylamide

Guidance literature:: With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; for 15h;
DOI:10.1007/BF00763666

Reference yield:

: 119840-20-9
ethyl (E)-3-(2,4-dichloro-6-methyl-5-pyrimidinyl)-2-propenoate

: 119840-23-2
(E)-3-(2,4-Dimethoxy-6-methyl-pyrimidin-5-yl)-N-(1-hydroxymethyl-2-methylsulfanylmethylsulfanyl-ethyl)-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 74.4 percent / 5 N aq. NaOH / 5 h

2: 1.) isobutyl chlorocarbonate, triethylamine, 2.) triethylamine / 1.) CH₃CN, 10 min, 2.) CH₃CN, room temp., overnight

3: 66.7 percent / NaBH₄, LiCl / tetrahydrofuran / 15 h

With sodium hydroxide; sodium tetrahydroborate; triethylamine; lithium chloride; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1007/BF00763666

Reference yield:

: 119840-21-0
(E)-β-(2,4-dimethoxy-6-methylpyrimidin-5-yl)acrylic acid

: 119840-23-2
(E)-3-(2,4-Dimethoxy-6-methyl-pyrimidin-5-yl)-N-(1-hydroxymethyl-2-methylsulfanylmethylsulfanyl-ethyl)-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) isobutyl chlorocarbonate, triethylamine, 2.) triethylamine / 1.) CH₃CN, 10 min, 2.) CH₃CN, room temp., overnight

2: 66.7 percent / NaBH₄, LiCl / tetrahydrofuran / 15 h

With sodium tetrahydroborate; triethylamine; lithium chloride; isobutyl chloroformate; In tetrahydrofuran;
DOI:10.1007/BF00763666