ethyl (E)-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enoate

Base Information

Chemical Name:ethyl (E)-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enoate
CAS No.:28277-68-1
Molecular Formula:C10H12 N2 O4
Molecular Weight:224.216
Hs Code.:
NSC Number:159935
DSSTox Substance ID:DTXSID501135223
ChEMBL ID:CHEMBL1991437
Mol file:28277-68-1.mol

Synonyms:28277-68-1;NSC159935;ethyl (E)-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enoate;CHEMBL1991437;DTXSID501135223;CCG-35208;STK565600;AKOS000509742;AKOS005492623;NSC-159935;SR-01000484891;SR-01000484891-1;ethyl (2E)-3-(2,4-dihydroxy-6-methylpyrimidin-5-yl)prop-2-enoate;3-(6-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acrylic acid ethyl este;Ethyl (2E)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-2-propenoate

Suppliers and Price of ethyl (E)-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of ethyl (E)-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enoate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.294g/cm³
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:224.07970687
Heavy Atom Count:16
Complexity:396

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C=CC1=C(NC(=O)NC1=O)C
Isomeric SMILES:CCOC(=O)/C=C/C1=C(NC(=O)NC1=O)C

Technology Process of ethyl (E)-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enoate

There total 5 articles about ethyl (E)-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde: 24048-74-6
1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinecarbaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 28277-68-1
Ethyl (E)-3-(2,4-Dioxo-6-methyl-5-pyrimidinyl)acrylate

Guidance literature:: In dimethyl sulfoxide; at 25 ℃; for 50h;
DOI:10.1021/jo00208a022

Reference yield:

: 147-61-5
5-hydroxymethyl-6-methyluracil

: 28277-68-1
Ethyl (E)-3-(2,4-Dioxo-6-methyl-5-pyrimidinyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / ceric ammonium nitrate / H₂O / 25 °C

2: 75 percent / dimethylsulfoxide / 50 h / 25 °C

With ammonium cerium(IV) nitrate; In water; dimethyl sulfoxide;
DOI:10.1021/jo00208a022

Reference yield:

: 626-48-2
6-Methyluracil

: 28277-68-1
Ethyl (E)-3-(2,4-Dioxo-6-methyl-5-pyrimidinyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / aq. NaOH / H₂O / 40 h / 25 °C

2: 60 percent / ceric ammonium nitrate / H₂O / 25 °C

3: 75 percent / dimethylsulfoxide / 50 h / 25 °C

With sodium hydroxide; ammonium cerium(IV) nitrate; In water; dimethyl sulfoxide;
DOI:10.1021/jo00208a022