JWH 081 7-methoxynaphthyl isomer

Base Information

• Chemical Name: JWH 081 7-methoxynaphthyl isomer
• CAS No.: 824961-61-7
• Molecular Formula: C₂₅H₂₅NO₂
• Molecular Weight: 371.479
• Hs Code.: 2933990090
• Mol file: 824961-61-7.mol

Synonyms:JWH-164;

Chemical Property of JWH 081 7-methoxynaphthyl isomer

Chemical Property:

• PSA: 31.23000
• LogP: 6.22430

Purity/Quality:

99% ^*data from raw suppliers

(7-Methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of JWH 081 7-methoxynaphthyl isomer

There total 4 articles about JWH 081 7-methoxynaphthyl isomer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-pentyl-1H-indole (59529-21-4) + 7-methoxynaphthalene-1-carboxylic acid (7498-58-0) → (7-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (824961-61-7)

Guidance literature:

7-methoxynaphthalene-1-carboxylic acid; With oxalyl dichloride; In dichloromethane; for 1h; Heating;

1-pentyl-1H-indole; With ethylaluminum dichloride; In toluene; for 18h;

DOI:10.1016/j.bmc.2004.09.050

Reference yield: 66.0%

→ (7-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (824961-61-7)

Guidance literature:

Reference yield:

6-methoxy-1-naphthol (22604-07-5) → (7-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (824961-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 84 percent / pyridine / 18 h / 20 °C

2.1: 54 percent / 1,3-bis(diphenylphosphino)propane; triethylamine; formic acid / Pd(OAc)2 / dimethylformamide / 6 h / 20 °C

3.1: oxalyl chloride / CH₂Cl₂ / 1 h / Heating

3.2: 66 percent / EtAlCl₂ / toluene / 18 h

With pyridine; formic acid; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; 3.2: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2004.09.050

upstream raw materials:

1-pentyl-1H-indole

7-methoxynaphthalene-1-carboxylic acid

6-methoxy-1-naphthol

6-(methyloxy)-1-naphthalenyl trifluoromethanesulfonate