22604-07-5

Basic information

• Product Name: 1-Naphthalenol,6-methoxy-
• Synonyms: 1-Naphthol,6-methoxy- (6CI,7CI,8CI);1-Hydroxy-6-methoxynaphthalene;6-Methoxy-1-naphthol;6-Methoxynaphthalen-1-ol
• CAS NO: 22604-07-5
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.1959
• EINECS: 200-589-5
• Mol File: 22604-07-5.mol

Chemical Properties

• Melting Point: 85 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 336.678 °C at 760 mmHg
• Flash Point: 211.849 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 5.65E-05mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.26±0.40(Predicted)
• CAS DataBase Reference: 1-Naphthalenol,6-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthalenol,6-methoxy-(22604-07-5)
• EPA Substance Registry System: 1-Naphthalenol,6-methoxy-(22604-07-5)

Safety Data

• Hazardous Substances Data: 22604-07-5(Hazardous Substances Data)

Usage

Uses

Used in Laboratory Applications:
1-Naphthalenol,6-methoxyis used as a pH indicator for monitoring the acidity or alkalinity of solutions in laboratory settings. Its color change properties make it a valuable tool for scientific research and experiments.
Used in Scientific Research:
1-Naphthalenol,6-methoxyis used as a pH indicator in various scientific research projects, allowing researchers to accurately measure and analyze the pH levels of different substances and solutions. This is crucial for understanding chemical reactions and processes that are dependent on pH conditions.

InChI:InChI=1/C11H10O2/c1-13-9-5-6-10-8(7-9)3-2-4-11(10)12/h2-7,12H,1H3

Upstream product

• 1258740-24-7 (R)-3-(benzyloxycarbonylamino)-4-(3-methoxyphenyl)butanoic acid 
• 1258740-26-9 (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 69769-74-0 4,6-dimethoxy-1-naphthylbenzyl ketone 
• 42200-95-3 4,6-dimethoxy-1-naphthylmethyl ketone 
• 67-56-1 methanol 
• 575-44-0 1,6-dihydroxynaphthalene 

Downstream Products

• 7498-58-0 7-methoxynaphthalene-1-carboxylic acid 

Relevant articles and documents

Synthesis of substituted (S)-2-aminotetralins via ring-opening of aziridines prepared from l-aspartic acid β-tert-butyl ester

This paper describes the total synthesis of the hydrochloride salts of (2S)-2-amino-7-methoxytetralin (21-HCl) and (2S)-2-amino-6-fluoro-7- methoxytetralin (ST1214), from a common enantiomerically pure aziridine 4b, which was available from l-aspartic acid β-tert-butyl ester. The synthesis of 21-HCl and ST1214 proceeded in nine steps and 5 and 6% overall yields, respectively. Key steps are the regioselective ring-opening of 4b with ArMgBr/CuBr·SMe2 and the intramolecular Friedel-Crafts cyclisation providing α-tetralone. Substituted naphthalenes were formed as side products in the latter reaction.

Regioselective Monomethylation of Unsymmetrical Naphthalenediols with Methanolic HCl

Treatment of naphthalene-1,3-diol and naphthalene-1,7-diol with methanol containing dry hydrogen chloride at room temperature gives exclusively 3-methoxy-1-naphthol and 7-methoxy-1-naphthol, respectively.Of the other two unsymmetrical naphthalenediols, the 1,2-isomer was unreactive and the 1,6-isomer gave a mixture of regioisomers under the same conditions.Two symmetrical diols (the 1,5- and 2,7-isomers) examined by the same procedure gave the monomethyl ethers in 60-70percent yields.

N-1H-tetrazol-5-yl-2-naphthalene carboxamides and their use as antiallergy and antiinflammatory agents

Novel naphthalene derivatives having antiallergy and antiinflammatory activity.

Efficient syntheses of some 1-naphthylalkyl ketones and studies on their autooxidation in basic medium

Birch reductions of 4,6-dimethoxy-1-naphthylalkyl ketones 1 provided in fair to good yields the demethoxylated products, 6-methoxy-1-naphthylalkyl ketones 2(a-g), not easily accessible by other procedures. Autooxidation of these ketones in basic medium afforded the diketones 6(a-c), the acid 2h, and interestingly the phenol 5. Extension of this reduction to the related tricyclic ketone 8 afforded 9a, the phenolic ketone 9b; and significantly the dihydrocoumarin derivative 10 as a result of autooxidation of 9a. The mechanisms for demethoxylation and autooxidation have been discussed.