1H-Tetrazole, 5-[[(2R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylpropyl]sulfonyl]- 1-phenyl-

Base Information

• Chemical Name: 1H-Tetrazole, 5-[[(2R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylpropyl]sulfonyl]- 1-phenyl-
• CAS No.: 824982-83-4
• Molecular Formula: C17H28N4O3SSi
• Molecular Weight: 396.586
• Mol file: 824982-83-4.mol

Synonyms:(2R)-5-[3-(tert-butyldimethylsilyloxy)-2-methylpropane-1-sulfonyl]-1-phenyl-1H-tetrazole;5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propane-1-sulfonyl]-1-phenyl-1H-tetrazole;

Chemical Property of 1H-Tetrazole, 5-[[(2R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylpropyl]sulfonyl]- 1-phenyl-

Chemical Property:

• PSA: 95.35000
• LogP: 4.17470

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Tetrazole, 5-[[(2R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylpropyl]sulfonyl]- 1-phenyl-

There total 2 articles about 1H-Tetrazole, 5-[[(2R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylpropyl]sulfonyl]- 1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(+)-5-[3-(tert-butyldimethylsilanyloxy)-2-methylpropylsulfanyl]-1-phenyl-1H-tetrazole (824982-82-3) → (-)-5-[3-(tert-butyldimethylsilanyloxy)-2-methylpropane-1-sulfonyl]-1-phenyl-1H-tetrazole (824982-83-4)

Guidance literature:

With sodium periodate; rhodium(III) chloride hydrate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 5h;

DOI:10.1016/j.tet.2014.04.079

Reference yield:

(S)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol (105859-45-8) + 1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → (-)-5-[3-(tert-butyldimethylsilanyloxy)-2-methylpropane-1-sulfonyl]-1-phenyl-1H-tetrazole (824982-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: sodium periodate; rhodium(III) chloride hydrate / tetrachloromethane; acetonitrile; water / 5 h / 20 °C

With sodium periodate; rhodium(III) chloride hydrate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; water; acetonitrile;

DOI:10.1016/j.tet.2014.04.079

upstream raw materials:

(+)-5-[3-(tert-butyldimethylsilanyloxy)-2-methylpropylsulfanyl]-1-phenyl-1H-tetrazole

(S)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol

1-Phenyl-1H-tetrazole-5-thiol