(2S)-3-{[Tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-1-OL

Base Information

• Chemical Name: (2S)-3-{[Tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-1-OL
• CAS No.: 105859-45-8
• Molecular Formula: C10H24O2Si
• Molecular Weight: 204.385
• DSSTox Substance ID: DTXSID40471331
• Nikkaji Number: J994.156H
• Wikidata: Q82299822
• Mol file: 105859-45-8.mol

Synonyms:105859-45-8;(2S)-3-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-2-METHYLPROPAN-1-OL;(2S)-3-[tert-butyl(dimethyl)silyl]oxy-2-methylpropan-1-ol;(S)-3-((tert-Butyldimethylsilyl)oxy)-2-methylpropan-1-ol;(2S)-3-((TERT-BUTYLDIMETHYLSILYL)OXY)-2-METHYLPROPAN-1-OL;(2S)-3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-2-METHYLPROPAN-1-OL;DTXSID40471331;AKOS030240571;AT38196;CS-0440329;EN300-25396871;J-001493;(s)-2-methyl-3-(t-butyldimethylsilyloxy)-1-propanol;(2S)-3-[[TERT-BUTYL(DIMETHYL)SILYL]OXY]-2-METHYL-1-PROPANOL

Chemical Property of (2S)-3-{[Tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-1-OL

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Boiling Point: 232.222oC at 760 mmHg
• PKA: 14.80±0.10(Predicted)
• Flash Point: 94.245oC
• PSA: 29.46000
• Density: 0.875g/cm3
• LogP: 2.63660
• Storage Temp.: -20°C Freezer
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly), Dichloromethane (Sparingly), Eth
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 204.154556538
• Heavy Atom Count: 13
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

(2S)-3-[[tert-Butyl(dimethyl)silyl]oxy]-2-methylpropan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)CO[Si](C)(C)C(C)(C)C
• Isomeric SMILES: C[C@@H](CO)CO[Si](C)(C)C(C)(C)C

Technology Process of (2S)-3-{[Tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-1-OL

There total 18 articles about (2S)-3-{[Tert-butyl(dimethyl)silyl]oxy}-2-methylpropan-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate (105859-44-7) → (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol (105859-45-8)

Guidance literature:

methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate; With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.5h;

With sodium hydroxide; water; In hexane; dichloromethane; tert-butyl methyl ether; at 20 ℃;

Reference yield: 90.0%

(1,1-dimethylethyl)(dimethyl){[(2S)-2-methyl-3-({[4-(methyloxy)phenyl]methyl}oxy)propyl]oxy}silane (882039-16-9) → (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol (105859-45-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tert-butyl methyl ether; under 760.051 Torr; Inert atmosphere;

DOI:10.1002/chem.200901064

Reference yield: 85.0%

(1R,3R,4S)-p-menthan-3-yl (2R)-3-(dimethyl-t-butylsiloxy-2-methyl)propionate (122778-41-0) → (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol (105859-45-8)

Guidance literature:

With diisobutylaluminum hydride; In tetrahydrofuran; hexane; at -20 ℃; for 1h;

upstream raw materials:

vinyl acetate

3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methylpropan-1-ol

methyl (R)-2-methyl-3-[(tert-butyldimethylsilyl)oxy]propionate

(1R,3R,4S)-p-menthan-3-yl (2R)-3-(dimethyl-t-butylsiloxy-2-methyl)propionate

Downstream raw materials:

(2S,6Z,9S,10E)-1,9-Bis[(1,1-dimethylethyl)dimethylsilyloxy]-11-(2-methylthiazol-4-yl)-2,6,10-trimethyl-undeca-6,10-diene

(-)-(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-methylbutyl phenyl sulfone

4-[(1E,3S,5Z,8R/S,10S)-3,11-bis{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-8-(phenylsulfonyl)undeca-1,5-dienyl]-2-methyl-1,3-thiazole