1H-BenziMidazole, 6-(4-MorpholinylMethyl)-2-(4-nitro-1H-pyrazol-3-yl)-

Base Information

Chemical Name:1H-BenziMidazole, 6-(4-MorpholinylMethyl)-2-(4-nitro-1H-pyrazol-3-yl)-
CAS No.:825619-29-2
Molecular Formula:C15H16N6O3
Molecular Weight:328.32600
Hs Code.:
Mol file:825619-29-2.mol

Synonyms:

Suppliers and Price of 1H-BenziMidazole, 6-(4-MorpholinylMethyl)-2-(4-nitro-1H-pyrazol-3-yl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
1H-Benzimidazole,6-(4-morpholinylmethyl)-2-(4-nitro-1H-pyrazol-3-yl)-
1g
$ 1500.00

Chemenu
4-((2-(4-Nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazol-5-yl)methyl)morpholine 95%+
1g
$ 2925.00

Chemenu
4-((2-(4-Nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazol-5-yl)methyl)morpholine 95%+
250mg
$ 1268.00

Chemenu
4-((2-(4-Nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazol-5-yl)methyl)morpholine 95%+
100mg
$ 702.00

Total 6 raw suppliers

Chemical Property of 1H-BenziMidazole, 6-(4-MorpholinylMethyl)-2-(4-nitro-1H-pyrazol-3-yl)-

Chemical Property:

PSA：115.65000
LogP:2.15450

Purity/Quality:

NLT 98% ^*data from raw suppliers

1H-Benzimidazole,6-(4-morpholinylmethyl)-2-(4-nitro-1H-pyrazol-3-yl)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-BenziMidazole, 6-(4-MorpholinylMethyl)-2-(4-nitro-1H-pyrazol-3-yl)-

There total 6 articles about 1H-BenziMidazole, 6-(4-MorpholinylMethyl)-2-(4-nitro-1H-pyrazol-3-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 825619-02-1
4-morpholin-4-ylmethylbenzene-1,2-diamine

: 5334-40-7
4-nitro-1H-pyrazole-3-carboxylic acid

: 825619-29-2
4-((2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazole-5-yl)methyl)morpholine

Guidance literature:: 4-morpholin-4-ylmethylbenzene-1,2-diamine; 4-nitro-1H-pyrazole-3-carboxylic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With acetic acid; for 3h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 825619-03-2
4-(3,4-dinitrobenzyl)-morpholine

: 825619-29-2
4-((2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazole-5-yl)methyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5%-palladium/activated carbon; hydrogen / ethanol / 48 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

2.2: 3 h / Reflux

With 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.04.039

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 825619-29-2
4-((2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazole-5-yl)methyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 6 h / Reflux

2.1: triethylamine / tetrahydrofuran / 2 h / 0 - 5 °C

2.2: 10 - 20 °C

3.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 0 °C / Reflux

4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 48 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

5.2: 3 h / Reflux

With sodium tetrahydroborate; thionyl chloride; 5%-palladium/activated carbon; boron trifluoride diethyl etherate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.04.039