4-(MorpholinoMethyl)benzene-1,2-diaMine

Base Information

• Chemical Name: 4-(MorpholinoMethyl)benzene-1,2-diaMine
• CAS No.: 825619-02-1
• Molecular Formula: C11H17N3O
• Molecular Weight: 207.275
• Hs Code.: 2934999090
• Mol file: 825619-02-1.mol

Synonyms:4-(morpholin-4-ylmethyl)benzene-1,2-diamine;

Chemical Property of 4-(MorpholinoMethyl)benzene-1,2-diaMine

Chemical Property:

• Boiling Point: 372.3±37.0 °C(Predicted)
• PKA: 7.42±0.10(Predicted)
• PSA: 64.51000
• Density: 1.209±0.06 g/cm3(Predicted)
• LogP: 1.78350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-(Morpholinomethyl)benzene-1,2-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(MorpholinoMethyl)benzene-1,2-diaMine

There total 5 articles about 4-(MorpholinoMethyl)benzene-1,2-diaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

4-(3,4-dinitrobenzyl)-morpholine (825619-03-2) → 4-morpholin-4-ylmethylbenzene-1,2-diamine (825619-02-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate;

Reference yield:

3,4-dinitrobenzoic acid (528-45-0) → 4-morpholin-4-ylmethylbenzene-1,2-diamine (825619-02-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 6 h / Reflux

2.1: triethylamine / tetrahydrofuran / 2 h / 0 - 5 °C

2.2: 10 - 20 °C

3.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 0 °C / Reflux

4.1: 5%-palladium/activated carbon; hydrogen / ethanol / 48 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; 5%-palladium/activated carbon; boron trifluoride diethyl etherate; hydrogen; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2013.04.039

Reference yield:

(3,4-dinitrophenyl)(morpholin-4-yl)methanone (65003-28-3) → 4-morpholin-4-ylmethylbenzene-1,2-diamine (825619-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 0 °C / Reflux

2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 48 h / 20 °C

With sodium tetrahydroborate; 5%-palladium/activated carbon; boron trifluoride diethyl etherate; hydrogen; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2013.04.039

upstream raw materials:

4-(3,4-dinitrobenzyl)-morpholine

3,4-dinitrobenzoic acid

3,4-dinitrobenzoyl chloride

(3,4-dinitrophenyl)(morpholin-4-yl)methanone

Downstream raw materials:

4-((2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazole-5-yl)methyl)morpholine

[3-(2-amino-4-morpholin-4-ylmethyl-phenylcarbamoyl)-1H-pyrazol-4-yl]-carbamic acid tert-butyl ester

N-{4-[4-chloro-6-({3-[5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl]-1H-pyrazol-4-yl}amino)pyrimidin-2-ylthio]phenyl}cyclopropanecarboxamide