4-Hydroxy-8-methoxy-2-phenylquinoline

Base Information

• Chemical Name: 4-Hydroxy-8-methoxy-2-phenylquinoline
• CAS No.: 825620-16-4
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.285
• DSSTox Substance ID: DTXSID40355884
• Nikkaji Number: J548.610F
• Wikidata: Q82134961
• ChEMBL ID: CHEMBL15706
• Mol file: 825620-16-4.mol

Synonyms:4-Hydroxy-8-methoxy-2-phenylquinoline;825620-16-4;8-Methoxy-2-phenyl-1H-quinolin-4-one;8-methoxy-2-phenyl-4-quinolinol;8-methoxy-2-phenylquinolin-4-ol;CHEMBL15706;AE-562/12222928;SCHEMBL6534525;DTXSID40355884;BDBM50044970;MFCD01464070;CCG-127022

Chemical Property of 4-Hydroxy-8-methoxy-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 1.27E-07mmHg at 25°C
• Boiling Point: 430.7oC at 760 mmHg
• Flash Point: 214.3oC
• PSA: 42.35000
• Density: 1.206g/cm3
• LogP: 3.61600
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 251.094628657
• Heavy Atom Count: 19
• Complexity: 371

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

4-HYDROXY-8-METHOXY-2-PHENYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1NC(=CC2=O)C3=CC=CC=C3

Technology Process of 4-Hydroxy-8-methoxy-2-phenylquinoline

There total 3 articles about 4-Hydroxy-8-methoxy-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(E)-2-Methoxy-phenylimino]-3-phenyl-propionamide → 8-methoxy-2-phenylquinolin-4-ol (57183-52-5,825620-16-4)

Guidance literature:

With pyrophosphoric acid; at 135 ℃; for 1h;

DOI:10.1021/jm0494523

Reference yield:

3-oxo-3-phenylpropanamide (3446-58-0) → 8-methoxy-2-phenylquinolin-4-ol (57183-52-5,825620-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: o-anisidine hydrochloride / toluene / Heating

2: pyrophosphoric acid / 1 h / 135 °C

With 2-methoxyaniline hydrochloride; pyrophosphoric acid; In toluene;

DOI:10.1021/jm0494523

Reference yield:

2-methoxy-phenylamine (90-04-0) → 8-methoxy-2-phenylquinolin-4-ol (57183-52-5,825620-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: o-anisidine hydrochloride / toluene / Heating

2: pyrophosphoric acid / 1 h / 135 °C

With 2-methoxyaniline hydrochloride; pyrophosphoric acid; In toluene;

DOI:10.1021/jm0494523

upstream raw materials:

3-oxo-3-phenylpropanamide

2-methoxy-phenylamine

Downstream raw materials:

4-chloro-8-methoxy-2-phenylquinoline