4-Chloro-8-methoxy-2-phenylquinoline

Base Information

Chemical Name:4-Chloro-8-methoxy-2-phenylquinoline
CAS No.:57183-54-7
Molecular Formula:C16H12ClNO
Molecular Weight:269.73
Hs Code.:
DSSTox Substance ID:DTXSID30560263
Wikidata:Q82443280
Mol file:57183-54-7.mol

Synonyms:4-Chloro-8-methoxy-2-phenylquinoline;57183-54-7;SCHEMBL6534440;DTXSID30560263;YCHPHWONKDEUAB-UHFFFAOYSA-N;MFCD12674818;4-chloro-8-methoxy-2-phenyl-quinoline

Suppliers and Price of 4-Chloro-8-methoxy-2-phenylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-CHLORO-8-METHOXY-2-PHENYLQUINOLINE 95.00%
5MG
$ 503.16

Total 4 raw suppliers

Chemical Property of 4-Chloro-8-methoxy-2-phenylquinoline

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:414.285°C at 760 mmHg
Flash Point:204.353°C
PSA：22.12000
Density:1.237g/cm³
LogP:4.56380
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:269.0607417
Heavy Atom Count:19
Complexity:293

Purity/Quality:

97% ^*data from raw suppliers

4-CHLORO-8-METHOXY-2-PHENYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC2=C1N=C(C=C2Cl)C3=CC=CC=C3

Technology Process of 4-Chloro-8-methoxy-2-phenylquinoline

There total 9 articles about 4-Chloro-8-methoxy-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 57183-52-5
8-methoxy-2-phenylquinolin-4(1H)-one

: 57183-54-7
4-chloro-8-methoxy-2-phenylquinoline

Guidance literature:: With trichlorophosphate; at 80 - 90 ℃; for 1h;
DOI:10.1016/j.bmc.2005.12.017

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 57183-54-7
4-chloro-8-methoxy-2-phenylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / K₂CO₃ / dimethylformamide / 3 h / 140 °C

2.1: diphenyl ether / 0.5 h / 260 - 280 °C

2.2: NaOH / ethanol / 18 h / Heating

2.3: 83 percent / hydrochloric acid / 5 h / Heating

3.1: 95 percent / POCl₃ / 1 h / 80 - 90 °C

With potassium carbonate; trichlorophosphate; In diphenylether; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.12.017

Reference yield:

: 886988-15-4
2-[(2-methoxyphenylamino)phenylmethylene]malonic acid diethyl ester

: 57183-54-7
4-chloro-8-methoxy-2-phenylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: diphenyl ether / 0.5 h / 260 - 280 °C

1.2: NaOH / ethanol / 18 h / Heating

1.3: 83 percent / hydrochloric acid / 5 h / Heating

2.1: 95 percent / POCl₃ / 1 h / 80 - 90 °C

With trichlorophosphate; In diphenylether;
DOI:10.1016/j.bmc.2005.12.017