2-chloro-N-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetaMide

Base Information

Chemical Name:2-chloro-N-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetaMide
CAS No.:825630-79-3
Molecular Formula:C14H19BClNO3
Molecular Weight:295.574
Hs Code.:
Mol file:825630-79-3.mol

Synonyms:2-chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide;

Suppliers and Price of 2-chloro-N-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-Chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 95%
500mg
$ 302.00

Matrix Scientific
2-Chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 95%
1g
$ 452.00

A1 Biochem Labs
2-Chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 95%
1 g
$ 350.00

Total 3 raw suppliers

Chemical Property of 2-chloro-N-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetaMide

Chemical Property:

PSA：47.56000
LogP:2.23610

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-chloro-N-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetaMide

There total 1 articles about 2-chloro-N-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 79-04-9
chloroacetyl chloride

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 825630-79-3
2-chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

Guidance literature:: With caesium carbonate; In dichloromethane; ethyl acetate; toluene;

Reference yield: 13.0%

: 825630-79-3
2-chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

: 591-50-4
iodobenzene

: methyl 5-(4-(pivaloyloxy)phenyl)pent-4-ynoate

: (E)-methyl 5-(4-(2-chloroacetamido)phenyl)-4-phenyl-5-(4-(pivaloyloxy)phenyl)pent-4-enoate

Guidance literature:: With bis(benzonitrile)palladium(II) dichloride; caesium carbonate; In water; N,N-dimethyl-formamide; at 45 ℃; for 12h;
DOI:10.1021/acs.jmedchem.6b01204

Reference yield:

: 825630-79-3
2-chloro-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide

: tert-butyl (3aR,6aS)-5-(2-((4-((E)-5-methoxy-5-oxo-2-phenyl-1-(4-(pivaloyloxy)phenyl)pent-1-en-1-yl)phenyl)amino)-2-oxoethyl)-3a,6a-dimethylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis(benzonitrile)palladium(II) dichloride; caesium carbonate / water; N,N-dimethyl-formamide / 12 h / 45 °C

2: sodium iodide; triethylamine / N,N-dimethyl-formamide / 80 °C

With bis(benzonitrile)palladium(II) dichloride; caesium carbonate; triethylamine; sodium iodide; In water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01204