Dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate

Base Information

• Chemical Name: Dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate
• CAS No.: 82577-49-9
• Molecular Formula: C15H14O6
• Molecular Weight: 290.273
• DSSTox Substance ID: DTXSID10358145
• Nikkaji Number: J3.230.260B
• Wikidata: Q82138476
• ChEMBL ID: CHEMBL1300942
• Mol file: 82577-49-9.mol

Synonyms:dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate;82577-49-9;HMS2275K11;SMR000141160;CBMicro_041822;MLS000533722;CHEMBL1300942;DTXSID10358145;STL325278;AKOS022113596;BIM-0041906.P001;SR-01000225907;SR-01000225907-1;dimethyl 2-(4-methoxyphenyl)-3,4-furandicarboxylate

Chemical Property of Dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 290.07903816
• Heavy Atom Count: 21
• Complexity: 374

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=C(C(=CO2)C(=O)OC)C(=O)OC

Technology Process of Dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate

There total 9 articles about Dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

dimethyl 3-(p-anisyl)-3,6-endoxotetrahydro-4,5-phthalate (82577-46-6) → dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate (82577-49-9)

Guidance literature:

at 190 - 200 ℃; under 26 Torr;

DOI:10.1007/BF00503545

Reference yield: 59.0%

C11H14O2S + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate (82577-49-9)

Guidance literature:

In dimethyl sulfoxide; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c9ra03563j

Reference yield: 57.0%

dimethyl acetylenedicarboxylate (762-42-5) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → dimethyl 2-(4-methoxyphenyl)furan-3,4-dicarboxylate (82577-49-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; In dichloromethane; at 25 - 30 ℃; for 4h;

DOI:10.1021/jo050903g

upstream raw materials:

dimethyl 3-(p-anisyl)-3,6-endoxotetrahydro-4,5-phthalate

dimethyl acetylenedicarboxylate

2-Bromo-4'-methoxyacetophenone

2-chloro-1-(4-methoxyphenyl)ethanone

Downstream raw materials:

dimethyl 2-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate

dimethyl 3-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)-2-oxo-2,3-dihydrofuran-3,4-dicarboxylate

dimethyl 2,2-bis(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3,4-dicarboxylate

dimethyl 3,5-bis(4-methoxyphenyl)-2-oxo-2,3-dihydrofuran-3,4-dicarboxylate