BOC-TYR(BZL)-ALDEHYDE

Base Information

• Chemical Name: BOC-TYR(BZL)-ALDEHYDE
• CAS No.: 82689-15-4
• Molecular Formula: C21H25NO4
• Molecular Weight: 355.434
• Mol file: 82689-15-4.mol

Synonyms:BOC-O-BENZYL-L-TYROSINE ALDEHYDE;Boc-Tyr (Bzl)-aldehyde;(S)-N-(tert-butoxycarbonyl)-O-benzyltyrosinal;BOC-TYR(BZL)-ALDEHYDE;N-(tert-butyloxycarbonyl)-O-benzyl-L-tyrosinal;31002 (S)-TERT-BUTYL 1-(4-(BENZYLOXY)PHENYL)-3-OXOPROPAN-2-YLCARBAMATE;[(S)-2-(4-Benzyloxy-phenyl)-1-formyl-ethyl]-carbamic acid tert-butyl ester;[(S)-1-(4-benzyloxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester;(S)-tert-butyl (1-(4-(benzyloxy)phenyl)-3-oxopropan-2-yl)carbamate;[2-(4-benzyloxy-phenyl)-1-formyl-ethyl]-carbamic acid tert-butyl ester;

Chemical Property of BOC-TYR(BZL)-ALDEHYDE

Chemical Property:

• Boiling Point: 501.4±50.0 °C(Predicted)
• PKA: 11.23±0.46(Predicted)
• PSA: 64.63000
• Density: 1.124±0.06 g/cm3(Predicted)
• LogP: 4.29120
• Storage Temp.: Store at 0°C

Purity/Quality:

99% ^*data from raw suppliers

Boc-Tyr(Bzl)-aldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-TYR(BZL)-ALDEHYDE

There total 12 articles about BOC-TYR(BZL)-ALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester (27513-44-6) → O-benzyl-N-(tert-butoxycarbonyl)-L-tyrosinal (82689-15-4)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2007.11.005

Reference yield: 83.0%

O-benzyl N-Boc-L-tyrosinol (66605-58-1) → O-benzyl-N-(tert-butoxycarbonyl)-L-tyrosinal (82689-15-4)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.bmc.2007.11.078

Reference yield: 77.0%

Boc-Tyr(OBz)-NCA (153815-62-4) → O-benzyl-N-(tert-butoxycarbonyl)-L-tyrosinal (82689-15-4)

Guidance literature:

With lithium tris[(3-ethyl-3-pentyl)oxy]aluminohydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/0040-4039(94)88419-6

upstream raw materials:

N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester

tert-butyl (S)-{3-[4-(benzyloxy)phenyl]-1-[methoxy(methyl)amino]-1-oxo-propan-2-yl}carbamate

O-benzyl N-Boc-L-tyrosinol

Boc-Tyr(OBz)-NCA

Downstream raw materials:

(3R,4S)-Ethyl 4-<(tert-butyloxycarbonyl)-amino>-2,2-difluoro-3-hydroxy-5-<4-(benzyloxy)phenyl>pentanoate

[(S)-1-(4-Benzyloxy-benzyl)-2-hydroxy-but-3-enyl]-carbamic acid tert-butyl ester

4-tert-butoxycarbonylamino-2,2-difluoro-3-hydroxy-5-[(4-benzyloxy)phenyl]pentanoic acid, ethyl ester