Benzamide, 2-amino-N-(4-chloro-2-iodophenyl)-5-fluoro-N-methyl-

Base Information

Chemical Name:Benzamide, 2-amino-N-(4-chloro-2-iodophenyl)-5-fluoro-N-methyl-
CAS No.:826991-78-0
Molecular Formula:C14H11ClFIN2O
Molecular Weight:404.61
Hs Code.:
DSSTox Substance ID:DTXSID50479560
Wikidata:Q82313666

Synonyms:826991-78-0;Benzamide, 2-amino-N-(4-chloro-2-iodophenyl)-5-fluoro-N-methyl-;DTXSID50479560

Suppliers and Price of Benzamide, 2-amino-N-(4-chloro-2-iodophenyl)-5-fluoro-N-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Benzamide, 2-amino-N-(4-chloro-2-iodophenyl)-5-fluoro-N-methyl-

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:403.95887
Heavy Atom Count:20
Complexity:360

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C1=C(C=C(C=C1)Cl)I)C(=O)C2=C(C=CC(=C2)F)N

Technology Process of Benzamide, 2-amino-N-(4-chloro-2-iodophenyl)-5-fluoro-N-methyl-

There total 3 articles about Benzamide, 2-amino-N-(4-chloro-2-iodophenyl)-5-fluoro-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 826991-70-2
5-fluoro-N-(4-chloro-2-iodo-phenyl)-N-methyl-2-nitro-benzamide

: 826991-78-0
2-amino-5-fluoro-N-(4-chloro-2-iodo-phenyl)-N-methyl-benzamide

Guidance literature:: With iron; acetic acid; In ethanol; for 5h; Heating;
DOI:10.1016/j.tet.2004.10.061

Reference yield:

: 394-02-5
5-fluoro-2-nitrobenzoyl chloride

: 826991-78-0
2-amino-5-fluoro-N-(4-chloro-2-iodo-phenyl)-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 5 h / 20 °C

2: 89 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C

3: 65 percent / AcOH; Fe dust / ethanol / 5 h / Heating

With iron; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.tet.2004.10.061

Reference yield:

: 826991-62-2
5-fluoro-N-(4-chloro-2-iodo-phenyl)-2-nitro-benzamide

: 826991-78-0
2-amino-5-fluoro-N-(4-chloro-2-iodo-phenyl)-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C

2: 65 percent / AcOH; Fe dust / ethanol / 5 h / Heating

With iron; sodium hydride; acetic acid; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2004.10.061