Carbamic acid, [2-[[[4-(diethylamino)phenyl]amino]carbonyl]-1,2,3,4-tetrahydro-2-naphth alenyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [2-[[[4-(diethylamino)phenyl]amino]carbonyl]-1,2,3,4-tetrahydro-2-naphth alenyl]-, 1,1-dimethylethyl ester
• CAS No.: 827022-78-6
• Molecular Formula: C26H35N3O3
• Molecular Weight: 437.582
• Mol file: 827022-78-6.mol

Synonyms:

Chemical Property of Carbamic acid, [2-[[[4-(diethylamino)phenyl]amino]carbonyl]-1,2,3,4-tetrahydro-2-naphth alenyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [2-[[[4-(diethylamino)phenyl]amino]carbonyl]-1,2,3,4-tetrahydro-2-naphth alenyl]-, 1,1-dimethylethyl ester

There total 2 articles about Carbamic acid, [2-[[[4-(diethylamino)phenyl]amino]carbonyl]-1,2,3,4-tetrahydro-2-naphth alenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-butoxycarbonylamino)-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid + N,N-diethylaniline (93-05-0) → tert-butyl 2-(((4-(diethylamino)phenyl)amino)carbonyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (827022-78-6)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 2h;

DOI:10.1021/jm0491750

Reference yield:

tert-butyl chloroformate (24608-52-4) + 2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (4-diethylaminophenyl)amide (827022-97-9) → tert-butyl 2-(((4-(diethylamino)phenyl)amino)carbonyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (827022-78-6)

Guidance literature:

With triethylamine;

DOI:10.1016/j.bmcl.2005.02.026

Reference yield: 97.0%

tert-butyl 2-(((4-(diethylamino)phenyl)amino)carbonyl)-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (827022-78-6) → 2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (4-diethylaminophenyl)amide (827022-97-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

DOI:10.1021/jm0491750

upstream raw materials:

N,N-diethylaniline

tert-butyl chloroformate

2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (4-diethylaminophenyl)amide

Downstream raw materials:

2-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (4-diethylaminophenyl)amide