(4-AMINO-PHENYL)-CARBAMIC ACID BENZYL ESTER

Base Information

• Chemical Name: (4-AMINO-PHENYL)-CARBAMIC ACID BENZYL ESTER
• CAS No.: 82720-42-1
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• Mol file: 82720-42-1.mol

Synonyms:(4-aminophenyl)carbamic acid benzyl ester;benzyl 4-aminophenylcarbamate;Carbamic acid,(4-aminophenyl)-,phenylmethyl ester;p-benzyloxycarbonylaminoaniline;4-benzyloxycarbonylamino-aniline;

Chemical Property of (4-AMINO-PHENYL)-CARBAMIC ACID BENZYL ESTER

Chemical Property:

• PSA: 64.35000
• LogP: 3.67170

Purity/Quality:

97% ^*data from raw suppliers

Benzyl(4-aminophenyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-AMINO-PHENYL)-CARBAMIC ACID BENZYL ESTER

There total 13 articles about (4-AMINO-PHENYL)-CARBAMIC ACID BENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 4-(benzoyloxycarbonylamido)phenylcarbamate (220741-56-0) → (4-Amino-phenyl)-carbamic acid benzyl ester (82720-42-1)

Guidance literature:

In 2,2,2-trifluoroethanol; at 150 ℃; for 2h; microwave irradiation;

DOI:10.1080/00397910802238718

Reference yield: 94.0%

benzyl 4-(nitro)phenylcarbamate (53821-12-8) → (4-Amino-phenyl)-carbamic acid benzyl ester (82720-42-1)

Guidance literature:

With Fe₃O₄Rh; hydrazine hydrate; In ethanol; at 80 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c0cc04816j

Reference yield: 92.0%

4-CbzNHC6H4N3 → (4-Amino-phenyl)-carbamic acid benzyl ester (82720-42-1)

Guidance literature:

With Decaborane; palladium on activated charcoal; In methanol; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(02)02106-8

upstream raw materials:

benzyl 4-(nitro)phenylcarbamate

benzyl chloroformate

1,4-phenylenediamine

(4-nitroso-phenyl)-carbamic acid benzyl ester

Downstream raw materials:

2-<4-(benzyloxycarboxamido)phenyl>-2-oxo-1,3,2-dioxaphospholane

benzyl {4-[(2,4-dihydroxyphenyl)methylidene]-aminophenyl}carbamate

benzyl {4-[(4-nitrophenyl)methylidene]aminophenyl}carbamate

Refernces

• 1、 Afanasyev, Oleg I.,Tsygankov, Alexey A.,Usanov, Dmitry L.,Chusov, Denis. "Dichotomy of reductive addition of amines to cyclopropyl ketones vs pyrrolidine synthesis". supporting information. p. 5968 - 5970. Retrieved 2016/11/29.
• 2、 -. "COMPOUNDS USEFUL AS CSF1 MODULATORS". Paragraph 00188; 00189. . Retrieved 2016/04/26.