1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-chloroethan-1-one

Base Information

Chemical Name:1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-chloroethan-1-one
CAS No.:827310-39-4
Molecular Formula:C19H19ClF2N2O
Molecular Weight:364.822
Hs Code.:
DSSTox Substance ID:DTXSID00589502
Wikidata:Q82482911

Synonyms:827310-39-4;1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-chloroethan-1-one;1-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-chloroethanone;SCHEMBL5446443;DTXSID00589502;AKOS003656969;1-{4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZINO}-2-CHLORO-1-ETHANONE

Suppliers and Price of 1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-chloroethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-chloroethan-1-one

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:364.1153973
Heavy Atom Count:25
Complexity:407

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CCl

Technology Process of 1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-chloroethan-1-one

There total 2 articles about 1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-chloroethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.13%

: 79-04-9
chloroacetyl chloride

: 27469-60-9
1-(4-fluorophenyl)methyl-piperazine

: 827310-39-4
N-(2-chloroacetyl)-N'-[bis(4-fluorophenyl)methyl]piperazine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.2174/1570180815666180501124009

Reference yield:

: 827310-39-4
N-(2-chloroacetyl)-N'-[bis(4-fluorophenyl)methyl]piperazine

Guidance literature:

Reference yield: 59.0%

: 827310-39-4
N-(2-chloroacetyl)-N'-[bis(4-fluorophenyl)methyl]piperazine

: 13754-38-6
N-Benzoylpiperazine

: N-[bis(4-fluorophenyl)methyl]-N'-{[4-benzoyl-1-piperazinyl]acetyl}piperazine

Guidance literature:: N-(2-chloroacetyl)-N'-[bis(4-fluorophenyl)methyl]piperazine; With potassium carbonate; In acetone; for 0.166667h;

N-Benzoylpiperazine; In acetone; at 20 ℃; for 48h;
DOI:10.2174/1570180815666180501124009